EP 1906976 A4 20111109 - THERAPEUTIC POLYMERS AND METHODS OF USE
Title (en)
THERAPEUTIC POLYMERS AND METHODS OF USE
Title (de)
THERAPEUTISCHE POLYMERE UND ANWENDUNGSVERFAHREN
Title (fr)
POLYMERES THERAPEUTIQUES ET LEURS PROCEDES D'UTILISATION
Publication
Application
Priority
- US 2006021395 W 20060602
- US 68757005 P 20050603
- US 75917906 P 20060113
Abstract (en)
[origin: WO2006132950A2] The present invention provides biodegradable therapeutic polymer compositions based on poly(ester amide) (PEA), poly(ester urethane) (PEUR), and poly(ester urea) (PEU) polymers useful for in vivo delivery of at least one therapeutic diol or di-acid incorporated into the backbone of the biodegradable polymer. The therapeutic polymer compositions biodegrade in vivo by enzymatic action to release therapeutic diols or di-acids from the polymer backbone in a controlled manner over time. The invention compositions are stable, can be lyophilized for transportation and storage, and can be redispersed for administration. Due to structural properties of the PEA and PEUR polymers used, the invention therapeutic polymer compositions provide for high loading of the therapeutic diol or di-acid, as well as optional bioactive agents.
IPC 8 full level
C08L 77/00 (2006.01); A61F 2/00 (2006.01); A61K 9/107 (2006.01); A61K 9/16 (2006.01); A61K 9/50 (2006.01); A61K 9/51 (2006.01); A61K 31/785 (2006.01); A61K 47/34 (2006.01); A61K 47/48 (2006.01); A61K 48/00 (2006.01); A61L 31/00 (2006.01); C07K 16/28 (2006.01); C08G 18/10 (2006.01); C08G 69/44 (2006.01); C08L 75/02 (2006.01); C08L 75/04 (2006.01); C08L 75/06 (2006.01); C08L 77/12 (2006.01); C12N 15/88 (2006.01)
CPC (source: EP)
A61K 31/785 (2013.01); A61K 47/58 (2017.07); A61K 47/59 (2017.07); A61K 47/593 (2017.07); A61K 47/595 (2017.07); A61K 48/0041 (2013.01); C08G 71/04 (2013.01); C08L 77/12 (2013.01)
Citation (search report)
- [XA] US 2002015720 A1 20020207 - KATSARAVA RAMAZ [GE], et al
- [E] EP 1945682 A2 20080723 - MEDIVAS LLC [US]
- [A] US 2002071822 A1 20020613 - UHRICH KATHRYN E [US]
- [A] SCHMELTZER R C ET AL: "Synthesis and cytotoxicity of salicylate-based poly(anhydride esters)", BIOMACROMOLECULES, ACS, WASHINGTON, DC, US, vol. 6, no. 1, 1 January 2005 (2005-01-01), pages 359 - 367, XP002482507, ISSN: 1525-7797, [retrieved on 20041126], DOI: 10.1021/BM049544+
- [A] WOO G L Y ET AL: "Synthesis and characterization of a novel biodegradable antimicrobial polymer", BIOMATERIALS, ELSEVIER SCIENCE PUBLISHERS BV., BARKING, GB, vol. 21, no. 12, 1 June 2000 (2000-06-01), pages 1235 - 1246, XP004195834, ISSN: 0142-9612, DOI: 10.1016/S0142-9612(00)00003-X
- [A] MAURO A.M CARAI ET AL: "Central effects of 1,4-butanediol are mediated by GABAB receptors via its conversion into [gamma]-hydroxybutyric acid", EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 441, no. 3, 1 April 2002 (2002-04-01), pages 157 - 163, XP055008078, ISSN: 0014-2999, DOI: 10.1016/S0014-2999(02)01502-9
- See references of WO 2006132950A2
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 2006132950 A2 20061214; WO 2006132950 A3 20070614; AU 2006255262 A1 20061214; CA 2610745 A1 20061214; EP 1906976 A2 20080409; EP 1906976 A4 20111109; JP 2008542393 A 20081127
DOCDB simple family (application)
US 2006021395 W 20060602; AU 2006255262 A 20060602; CA 2610745 A 20060602; EP 06760640 A 20060602; JP 2008514885 A 20060602