EP 1907005 A1 20080409 - COMPOSITIONS FOR AFFECTING WEIGHT LOSS
Title (en)
COMPOSITIONS FOR AFFECTING WEIGHT LOSS
Title (de)
ZUSAMMENSETZUNGEN ZUR FÖRDERUNG VON GEWICHTSVERLUST
Title (fr)
COMPOSITIONS SERVANT À AVOIR UN EFFET SUR LA PERTE DE POIDS
Publication
Application
Priority
- US 2006028875 W 20060724
- US 70287705 P 20050727
Abstract (en)
[origin: WO2007016108A1] Disclosed are compositions for affecting weight loss comprising a first compound and a second compound, where the first compound is a metabolite of naltrexone, such as 6-ß-naltrexol or a prodrug of a naltrexone metabolite, and the second compound causes increased agonism of a melanocortin 3 receptor (MC3-R) and/or a melanocortin 4 receptor (MC4-R), and/or increases the concentration of a-MSH in the central nervous system. Also disclosed are methods of affecting weight loss, increasing energy expenditure, increasing satiety in an individual, or suppressing the appetite of an individual, comprising identifying an individual in need thereof and treating that individual to antagonize opioid receptor activity with a metabolite of naltrexone, such as 6-ß-naltrexol or a prodrug of a naltrexone metabolite, and treating that individual to enhance a-MSH activity, e.g., by administration of a second compound causes increased agonism of MC3-R and/or MC4-R, and/or increases the concentration of a-MSH in the central nervous system.
IPC 8 full level
A61K 31/137 (2006.01); A61K 31/138 (2006.01); A61K 31/485 (2006.01); A61K 45/06 (2006.01); A61P 3/04 (2006.01)
CPC (source: EP KR US)
A61K 31/137 (2013.01 - EP KR US); A61K 31/138 (2013.01 - EP KR US); A61K 31/165 (2013.01 - EP US); A61K 31/485 (2013.01 - EP KR US); A61K 45/06 (2013.01 - EP US); A61P 3/04 (2017.12 - EP)
Citation (search report)
See references of WO 2007016108A1
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR
Designated extension state (EPC)
AL BA HR MK RS
DOCDB simple family (publication)
WO 2007016108 A1 20070208; WO 2007016108 B1 20070510; AU 2006275914 A1 20070208; BR PI0613911 A2 20110222; CA 2614539 A1 20070208; CN 101237886 A 20080806; EP 1907005 A1 20080409; IL 188442 A0 20080413; JP 2009502931 A 20090129; KR 20080042092 A 20080514; MX 2008001136 A 20080313; RU 2007147609 A 20090910; US 2007117827 A1 20070524
DOCDB simple family (application)
US 2006028875 W 20060724; AU 2006275914 A 20060724; BR PI0613911 A 20060724; CA 2614539 A 20060724; CN 200680027107 A 20060724; EP 06800325 A 20060724; IL 18844207 A 20071226; JP 2008524072 A 20060724; KR 20087004150 A 20080221; MX 2008001136 A 20060724; RU 2007147609 A 20060724; US 49268506 A 20060724