EP 1910251 A1 20080416 - METHOD FOR ISOLATING 5-SUBSTITUTED TETRAZOLES
Title (en)
METHOD FOR ISOLATING 5-SUBSTITUTED TETRAZOLES
Title (de)
VERFAHREN ZUR REINDARSTELLUNG VON 5-SUBSTITUIERTEN TETRAZOLEN
Title (fr)
PROCEDE POUR PURIFIER DES TETRAZOLES 5-SUBSTITUES
Publication
Application
Priority
- AT 2006000328 W 20060803
- AT 13172005 A 20050804
Abstract (en)
[origin: WO2007014412A1] The invention relates to a method for isolating 5-substituted tetrazoles of general formula (I) in which R represents a substituted biphenyl radical during which the ring closure, starting from a corresponding nitrile, is carried out in organic solvents while using alkali, alkaline-earth or organotin azides. The organic phases containing the nitrile and the tetrazol are firstly mixed with water while firstly forming three liquid phases, after which the aqueous phase containing the azide and the phase containing the nitrile are separated out, and the middle organic phase containing the tetrazol is subsequently processed. In the case of ester groups to be saponified, this phase is mixed with alkali lye, after which the organic phase is separated out and the aqueous phase is acidified or otherwise, this phase is immediately acidified and purified.
IPC 8 full level
C07B 63/00 (2006.01); C07D 257/04 (2006.01); C07D 403/10 (2006.01); C07D 405/14 (2006.01)
CPC (source: EP KR US)
A61P 9/12 (2017.12 - EP); C07D 257/04 (2013.01 - EP KR US); C07D 403/10 (2013.01 - EP US); C07D 405/14 (2013.01 - EP KR US)
Citation (search report)
See references of WO 2007014412A1
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR
Designated extension state (EPC)
AL BA HR MK RS
DOCDB simple family (publication)
WO 2007014412 A1 20070208; AT 502219 A1 20070215; AT 502219 B1 20070415; CN 101253131 A 20080827; EP 1910251 A1 20080416; IL 189144 A0 20080807; JP 2009502975 A 20090129; KR 20080034448 A 20080421; US 2009203920 A1 20090813
DOCDB simple family (application)
AT 2006000328 W 20060803; AT 13172005 A 20050804; CN 200680028923 A 20060803; EP 06760815 A 20060803; IL 18914408 A 20080131; JP 2008524309 A 20060803; KR 20087002658 A 20080131; US 99737206 A 20060803