EP 1910525 A1 20080416 - MODULATION OF SPHINGOSINE KINASE SIGNALLING
Title (en)
MODULATION OF SPHINGOSINE KINASE SIGNALLING
Title (de)
MODULATION DER SPHINGOSINKINASE-SIGNALGEBUNG
Title (fr)
MODULATION DE LA SIGNALISATION DE LA SPHINGOSINE KINASE
Publication
Application
Priority
- AU 2006000867 W 20060621
- AU 2005903258 A 20050621
Abstract (en)
[origin: WO2006135969A1] The present invention relates generally to a method of modulating cellular activity and to agents for use therein. More particularly, the present invention provides a method of modulating the level of sphingosine kinase functional activity. In a related aspect, the present invention provides a method of modulating sphingosine kinase mediated signalling via modulation of its intracellular level of activity. The present invention still further extends to novel molecules which exhibit the capacity to induce sphingosine kinase activity. The methods and molecules of the present invention are useful, inter alia, in the treatment and/or prophylaxis of conditions characterised by aberrant, unwanted or otherwise inappropriate cellular functional activity and/or aberrant, unwanted or otherwise inappropriate sphingosine kinase mediated signalling. The present invention is further directed to methods for identifying and/or designing agents capable of modulating the level of sphingosine kinase activity.
IPC 8 full level
C12N 9/00 (2006.01); A61K 48/00 (2006.01); A61P 29/00 (2006.01); C12N 9/99 (2006.01)
CPC (source: EP)
A61P 1/00 (2017.12); A61P 9/10 (2017.12); A61P 11/06 (2017.12); A61P 29/00 (2017.12); A61P 35/00 (2017.12); A61P 37/00 (2017.12); A61P 43/00 (2017.12); C12N 9/1205 (2013.01); C12Y 207/01091 (2013.01); A61K 48/00 (2013.01)
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 2006135969 A1 20061228; CA 2612773 A1 20061228; EP 1910525 A1 20080416; EP 1910525 A4 20090506; JP 2008546393 A 20081225
DOCDB simple family (application)
AU 2006000867 W 20060621; CA 2612773 A 20060621; EP 06752621 A 20060621; JP 2008517275 A 20060621