EP 1912677 A2 20080423 - PSMA antibody-drug conjugates
Title (en)
PSMA antibody-drug conjugates
Title (de)
PSMA-Antikörper-Arzneimittel-Konjugate
Title (fr)
Conjugués anticorps PSMA-médicament
Publication
Application
Priority
- US 2006024182 W 20060620
- US 69239905 P 20050620
- US 79236006 P 20060414
Abstract (en)
[origin: WO2007002222A2] This invention relates generally to antibody-drag conjugates (ADCs). In particular,the invention relates to ADCs which comprise an antibody or antigen-binding fragmentthereof which binds to prostate-specific membrane antigen (PSMA) and is conjugated tomonomethylauristatin norephedrine or monomethylauristatin phenylalanine. The antibody- drug conjugate has a PC-3 cell to C4-2 or LNCaP cell selectivity of at least 250. Theinvention also relates, in part, to compositions of and methods of using the ADCs. Themethods provided include, for example, methods for treating a PSMA-mediated disease.
IPC 8 full level
A61K 47/48 (2006.01); A61P 35/00 (2006.01)
CPC (source: EP KR US)
A61K 31/337 (2013.01 - EP US); A61K 31/573 (2013.01 - EP KR US); A61K 38/191 (2013.01 - EP US); A61K 38/2013 (2013.01 - EP US); A61K 38/21 (2013.01 - EP KR US); A61K 39/395 (2013.01 - KR); A61K 47/50 (2017.07 - KR); A61K 47/6811 (2017.07 - EP US); A61K 47/6869 (2017.07 - EP US); A61K 47/6889 (2017.07 - EP US); A61P 35/00 (2017.12 - EP); A61P 43/00 (2017.12 - EP)
Citation (search report)
See references of WO 2007002222A2
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR
Designated extension state (EPC)
AL BA HR MK RS
DOCDB simple family (publication)
WO 2007002222 A2 20070104; WO 2007002222 A3 20070809; AU 2006262231 A1 20070104; AU 2006262231 B2 20130124; BR PI0612529 A2 20101123; CA 2612762 A1 20070104; CA 2612762 C 20131210; CN 101287498 A 20081015; CN 101287498 B 20130327; CN 103127523 A 20130605; DK 1912677 T3 20140113; EP 1912677 A2 20080423; EP 1912677 B1 20131002; ES 2440482 T3 20140129; HK 1116697 A1 20090102; JP 2008546792 A 20081225; JP 2013100314 A 20130523; JP 2015187117 A 20151029; JP 6063747 B2 20170118; KR 20080031296 A 20080408; KR 20140084242 A 20140704; KR 20150126978 A 20151113; NZ 565075 A 20110527; PL 1912677 T3 20140331; PT 1912677 E 20131223; US 2007160617 A1 20070712; US 2021023094 A1 20210128
DOCDB simple family (application)
US 2006024182 W 20060620; AU 2006262231 A 20060620; BR PI0612529 A 20060620; CA 2612762 A 20060620; CN 200680030241 A 20060620; CN 201310053174 A 20060620; DK 06785283 T 20060620; EP 06785283 A 20060620; ES 06785283 T 20060620; HK 08111269 A 20081013; JP 2008518359 A 20060620; JP 2013000244 A 20130104; JP 2015095276 A 20150507; KR 20087001546 A 20080118; KR 20147013703 A 20060620; KR 20157031397 A 20060620; NZ 56507506 A 20060620; PL 06785283 T 20060620; PT 06785283 T 20060620; US 202016921811 A 20200706; US 47145706 A 20060620