EP 1917006 A2 20080507 - USE OF INHIBITORS OF N-METHYL TRANSFERASES FOR THE THERAPY OF PARKINSON'S DISEASE
Title (en)
USE OF INHIBITORS OF N-METHYL TRANSFERASES FOR THE THERAPY OF PARKINSON'S DISEASE
Title (de)
VERWENDUNG VON INHIBITORN DER N-METHYLTRANSFERASEN IN DER THERAPIE DES PARKINSON-SYMDROMS
Title (fr)
UTILISATION D'INHIBITEURS DE N-METHYLTRANSFERASES DANS LA THERAPIE DE LA MALADIE DE PARKINSON
Publication
Application
Priority
- EP 2006006132 W 20060626
- DE 102005029468 A 20050624
Abstract (en)
[origin: DE102005029468A1] Exogenous or endogenous inhibitors of N-methyltransferase are used for the manufacture of a medicament for therapy and prophylaxis of Parkinson's syndrome. ACTIVITY : Antiparkinsonian. MECHANISM OF ACTION : N-methyltransferase inhibitor. A tripeptide, Ala-Cys-Cys, isolated from rabbit liver, was tested to inhibit phenylethanolamine-N-methyltransferase (PNMT) using biological assays. The results showed that the tripeptide exhibited inhibitory activity of 90%.
IPC 8 full level
A61K 31/00 (2006.01); A61K 31/137 (2006.01); A61K 31/47 (2006.01); A61K 31/55 (2006.01); A61K 31/5513 (2006.01); A61K 38/04 (2006.01); A61K 38/06 (2006.01); A61P 25/16 (2006.01)
CPC (source: EP US)
A61K 31/00 (2013.01 - EP US); A61K 31/137 (2013.01 - EP US); A61K 31/47 (2013.01 - EP US); A61K 31/55 (2013.01 - EP US); A61K 31/5513 (2013.01 - EP US); A61K 38/06 (2013.01 - EP US); A61P 25/16 (2017.12 - EP)
Citation (search report)
See references of WO 2006136454A2
Citation (examination)
CHRISOPH WILHELM: "Partielle Reinigung und Charakterisierung eines natürlich vorlommenden PNMT-Inhibitors aus Kaninchenleber", 1 January 2004, Ulm
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR
Designated extension state (EPC)
AL BA HR MK RS
DOCDB simple family (publication)
DE 102005029468 A1 20061228; EP 1917006 A2 20080507; US 2010143322 A1 20100610; WO 2006136454 A2 20061228; WO 2006136454 A3 20071101
DOCDB simple family (application)
DE 102005029468 A 20050624; EP 06754568 A 20060626; EP 2006006132 W 20060626; US 99373806 A 20060626