Global Patent Index - EP 1917034 A4

EP 1917034 A4 20090429 - A CA6 ANTIGEN-SPECIFIC CYTOTOXIC CONJUGATE AND METHODS OF USING THE SAME

Title (en)

A CA6 ANTIGEN-SPECIFIC CYTOTOXIC CONJUGATE AND METHODS OF USING THE SAME

Title (de)

CA6-ANTIGENSPEZIFISCHES ZYTOTOXISCHES KONJUGAT UND VERFAHREN ZU DESSEN ANWENDUNG

Title (fr)

CONJUGUE CYTOTOXIQUE SPECIFIQUE DE L'ANTIGENE CA6 ET METHODES D'UTILISATION DE CE DERNIER

Publication

EP 1917034 A4 20090429 (EN)

Application

EP 05788869 A 20050822

Priority

US 2005030115 W 20050822

Abstract (en)

[origin: WO2007024222A1] Cytotoxic conjugates comprising a cell binding agent and a cytotoxic agent, therapeutic compositions comprising the conjugate, methods for using the conjugates in the inhibition of cell growth and the treatment of disease, and a kit comprising the cytotoxic conjugate are disclosed are all embodiments of the invention. In particular, the cell binding agent is a monoclonal antibody, and epitope-binding fragments thereof, that recognizes and binds the CA6 glycotope. The present invention is also directed to humanized or resurfaced versions of DS6, an anti-CA6 murine monoclonal antibody, and epitope-binding fragments thereof.

IPC 8 full level

A61K 39/395 (2006.01); C12N 5/06 (2006.01); C12P 21/06 (2006.01)

CPC (source: EP US)

A61K 47/6803 (2017.07 - EP US); A61K 47/68033 (2023.08 - EP US); A61K 47/6851 (2017.07 - EP); A61K 47/6877 (2017.07 - EP); A61P 35/00 (2017.12 - EP); C07K 16/30 (2013.01 - EP US); C07K 16/465 (2013.01 - EP); A61K 2039/505 (2013.01 - EP); C07K 2317/24 (2013.01 - EP); Y02A 50/30 (2017.12 - EP)

Citation (search report)

  • [A] US 2004241174 A1 20041202 - AMPHLETT GODFREY [US], et al
  • [A] CHUN P ET AL: "POTENT ANTI-CANCER ACTIVITY OF DS6-DM1, AN ANTIBODY-DRUG CONJUGATE TARGETING A MUC1 GLYCOTOPE ON OVARIAN, BREAST AND PANCREATIC CARCINOMAS", CLINICAL CANCER RESEARCH, THE AMERICAN ASSOCIATION FOR CANCER RESEARCH, US, vol. 9, no. SUPPL. 16, 1 December 2003 (2003-12-01), pages 6186S,ABSTRACTB205, XP008069628, ISSN: 1078-0432
  • [A] SMITH NL ET AL: "PATTERNS OF EXPRESSION OF THE DS6-GLYCOFORM OF MUC1 CORRELATES WITH KNOWN PROGNOSTIC INDICATORS IN BREAST CANCER", PROCEEDINGS OF THE ANNUAL MEETING OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH, NEW YORK, NY, vol. 45, 1 January 2004 (2004-01-01), pages 239,ABSTRACT1051, XP001247901, ISSN: 0197-016X
  • [A] SMITH N L ET AL: "IMMUNOHISTOCHEMICAL DISTRIBUTION OF TUMOR-ASSOCIATED ANTIGEN CA6 IN GYNECOLOGICAL NEOPLASMS AS DETECTED BY MONOCLONAL ANTIBODY DS6", INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY, NEW YORK, NY, US, vol. 20, no. 20, 1 July 2001 (2001-07-01), pages 260 - 266, XP002907224, ISSN: 0277-1691
  • [DA] KEARSE K P ET AL: "MONOCLONAL ANTIBODY DS6 DETECTS A TUMOR-ASSOCIATED SIALOGLYCOTOPE EXPRESSED ON HUMAN SEROUS OVARIAN CARCINOMAS", INTERNATIONAL JOURNAL OF CANCER, JOHN WILEY & SONS, INC, UNITED STATES, SWITZERLAND, GERMANY, vol. 88, no. 88, 1 January 2000 (2000-01-01), pages 866 - 872, XP002907222, ISSN: 0020-7136
  • See references of WO 2007024222A1

Citation (examination)

  • RUDIKOFF S ET AL: "Single amino acid substitution altering antigen-binding specificity", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES (PNAS), NATIONAL ACADEMY OF SCIENCE, US, vol. 79, 1 March 1982 (1982-03-01), pages 1979 - 1983, XP007901436, ISSN: 0027-8424, DOI: 10.1073/PNAS.79.6.1979
  • MACCALLUM R M ET AL: "Antibody-antigen interactions: Contact analysis and binding site topography", JOURNAL OF MOLECULAR BIOLOGY, LONDON, GB, vol. 262, no. 5, 1 January 1996 (1996-01-01), pages 732 - 745, XP002242391, ISSN: 0022-2836, DOI: 10.1006/JMBI.1996.0548

Designated contracting state (EPC)

AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR

Designated extension state (EPC)

AL BA HR MK YU

DOCDB simple family (publication)

WO 2007024222 A1 20070301; AU 2005335743 A1 20070301; BR PI0520509 A2 20090512; CA 2615761 A1 20070301; CN 101242855 A 20080813; EA 020130 B1 20140829; EA 020130 B9 20141030; EA 200800642 A1 20080829; EC SP088241 A 20080428; EP 1917034 A1 20080507; EP 1917034 A4 20090429; HK 1211965 A1 20160603; IL 189628 A0 20080605; IL 238798 A0 20150630; JP 2009504193 A 20090205; MX 2008002607 A 20080319; NO 20080893 L 20080522

DOCDB simple family (application)

US 2005030115 W 20050822; AU 2005335743 A 20050822; BR PI0520509 A 20050822; CA 2615761 A 20050822; CN 200580051368 A 20050822; EA 200800642 A 20050822; EC SP088241 A 20080305; EP 05788869 A 20050822; HK 15112923 A 20151231; IL 18962808 A 20080220; IL 23879815 A 20150513; JP 2008527882 A 20050822; MX 2008002607 A 20050822; NO 20080893 A 20080220