EP 1919875 A2 20080514 - PYRAZOLE DERIVATIVES AND THEIR USE AS PKA AND PKB MODULATORS
Title (en)
PYRAZOLE DERIVATIVES AND THEIR USE AS PKA AND PKB MODULATORS
Title (de)
PYRAZOLDERIVATE UND IHRE VERWENDUNG ALS PKA- UND PKB-MODULATOREN
Title (fr)
DERIVES DE LA PYRAZOLE COMME MODULATEURS DE PKA ET PKB
Publication
Application
Priority
- GB 2006002286 W 20060621
- GB 0512654 A 20050621
- US 69262005 P 20050621
- US 74365806 P 20060322
Abstract (en)
[origin: WO2006136829A2] The invention provides a compound of the formula (I) or a salt, solvate, tautomer or N-oxide thereof; wherein A is a saturated hydrocarbon linker group; E is a monocyclic or bicyclic carbocyclic or heterocyclic group; L<SUP>1</SUP> is a bond or a linker selected from C<SUB>1</SUB>-C<SUB>4</SUB> alkenylene, C<SUB>1</SUB>-C<SUB>4</SUB> alkynylene, -CONR', -NR'CO, -S, -C(O)-, -C(NR<SUP>11</SUP>)-, -C(S)-, -N(R<SUP>11</SUP>)<SUB>2</SUB>, C(=CHR<SUP>11</SUP>), -SO- and -SO<SUB>2-</SUB>; or L<SUP>1</SUP> together with t R<SUP>16</SUP> forms and 8-12 membered fused bicyclic heteroaryl ring system; L<SUP>3</SUP> is a bond or a linker selected from CONH and HNCO; provided that L<SUP>1</SUP> and L<SUP>3</SUP> cannot both be linkers simultaneously; and provided also that L<SUP>1</SUP> and L<SUP>3</SUP> cannot both be a bond simultaneously; R<SUP>16</SUP> is an optionally substituted 5- to 12-membered monocyclic or bicyclic carbocyclic or heterocyclic ring; L<SUP>2</SUP> is absent or is a linker selected from C]-C4 alkylene, Ci-C4 alkenylene, Ci-C4 alkynylene, -CONR'-, -NR'CO-, -O-, -S-, -C(O)-, C(=CHR<SUP>11</SUP>), C(S)-, -N(R<SUP>11</SUP>)<SUB>2</SUB>, C<SUB>3-4</SUB> cycloalkanediyl, -SO- and -SO2-; R<SUP>17</SUP> is absent or is C<SUB>1-6</SUB> alkyl or an optionally substituted 5 to 12 membered carbocyclic or heterocyclic ring; provided that when R<SUP>17</SUP> is absent, then L<SUP>2</SUP> is also absent; and R<SUP>2</SUP>, R<SUP>3</SUP>, R<SUP>4</SUP>, R<SUP>5</SUP>, R<SUP>11</SUP> and R' are as defined in the claims.
IPC 8 full level
C07D 231/12 (2006.01); C07D 401/10 (2006.01); C07D 401/12 (2006.01); C07D 401/14 (2006.01)
CPC (source: EP)
A61P 1/04 (2017.12); A61P 3/04 (2017.12); A61P 3/08 (2017.12); A61P 3/10 (2017.12); A61P 9/00 (2017.12); A61P 9/10 (2017.12); A61P 11/00 (2017.12); A61P 11/06 (2017.12); A61P 13/12 (2017.12); A61P 17/06 (2017.12); A61P 19/02 (2017.12); A61P 19/08 (2017.12); A61P 19/10 (2017.12); A61P 21/04 (2017.12); A61P 25/00 (2017.12); A61P 25/16 (2017.12); A61P 25/28 (2017.12); A61P 27/02 (2017.12); A61P 27/16 (2017.12); A61P 29/00 (2017.12); A61P 31/12 (2017.12); A61P 31/18 (2017.12); A61P 31/22 (2017.12); A61P 35/00 (2017.12); A61P 35/02 (2017.12); A61P 37/02 (2017.12); A61P 43/00 (2017.12); C07D 231/12 (2013.01); C07D 401/10 (2013.01); C07D 401/12 (2013.01); C07D 401/14 (2013.01); C07D 403/14 (2013.01); C07D 409/14 (2013.01); C07D 413/12 (2013.01); C07D 413/14 (2013.01); C07D 417/14 (2013.01)
Citation (search report)
See references of WO 2006136829A2
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 2006136829 A2 20061228; WO 2006136829 A3 20070215; EP 1919875 A2 20080514; JP 2008543919 A 20081204
DOCDB simple family (application)
GB 2006002286 W 20060621; EP 06755590 A 20060621; JP 2008517590 A 20060621