EP 1922545 A1 20080521 - FUNCTIONAL IN VITRO IMMUNOASSAY
Title (en)
FUNCTIONAL IN VITRO IMMUNOASSAY
Title (de)
FUNKTIONELLER IN VITRO IMMUNASSAY
Title (fr)
DOSAGE IMMUNOLOGIQUE IN VITRO FONCTIONNEL
Publication
Application
Priority
- DE 2006001604 W 20060908
- DE 2005001594 W 20050908
- EP 05090297 A 20051026
- EP 06791374 A 20060908
Abstract (en)
[origin: WO2007028380A1] The invention relates to a method for the in vitro monitoring of the effect of substances in in vivo processes and to an in vitro detection method, for identifying immunomodulating compounds and/or for detecting the effect of immunomodulating compounds as well as for identifying compounds which induce apoptosis and/or necrosis by means of the immune system in in vivo processes. The claimed methods are particularly suitable for monitoring the effects of substances on cells which are mediated by the immune system. Since cells of the immune system with the substances in the primary incubation can impart their effect thereon, the in vivo effects of the substances are monitored in the secondary incubation by incubating with target cells the supernatants or the mixture of cells and supernatant of the primary incubation, which contain, inter alia, the deposited products from the cells of the immune system. The claimed method is also suitable for the in vitro monitoring of the in vivo effects before, during and/or after the dosage of immunomodulating compounds as well as compounds that induce apoptosis and/or necrosis.
IPC 8 full level
G01N 33/50 (2006.01)
CPC (source: EP US)
G01N 33/5047 (2013.01 - EP US); G01N 33/56966 (2013.01 - EP US); G01N 2500/10 (2013.01 - EP US)
Citation (search report)
See references of WO 2007028380A1
Citation (examination)
- ROMANO CIRO ET AL: "Effects of preactivated autologous T lymphocytes on CD80, CD86 and CD95 expression by chronic lymphocytic leukemia B cells.", LEUKEMIA & LYMPHOMA NOV 2003 LNKD- PUBMED:14738151, vol. 44, no. 11, November 2003 (2003-11-01), pages 1963 - 1971, ISSN: 1042-8194
- ASSELIN-PATUREL CARINE ET AL: "Differential effect of high doses versus low doses of interleukin-12 on the adoptive transfer of human specific cytotoxic T lymphocyte in autologous lung tumors engrafted into severe combined immunodeficiency disease-nonobese diabetic mice: Relation with interleukin-10 induction", CANCER, vol. 91, no. 1, 1 January 2001 (2001-01-01), pages 113 - 122, ISSN: 0008-543X
- KUBOTA E ET AL: "Tumoricidal effect of human PBMC following stimulation with OK-432 and its application for locoregional immunotherapy in head and neck cancer patients.", JOURNAL OF CRANIO-MAXILLO-FACIAL SURGERY : OFFICIAL PUBLICATION OF THE EUROPEAN ASSOCIATION FOR CRANIO-MAXILLO-FACIAL SURGERY JAN 1993 LNKD- PUBMED:8445052, vol. 21, no. 1, January 1993 (1993-01-01), pages 30 - 37, ISSN: 1010-5182
- FARAONI ET AL: "A novel telomerase-based approach to detect natural cell-mediated cytotoxic activity against tumor cells in vitro", JOURNAL OF IMMUNOLOGICAL METHODS, ELSEVIER SCIENCE PUBLISHERS B.V.,AMSTERDAM, NL LNKD- DOI:10.1016/J.JIM.2005.07.015, vol. 305, no. 2, 30 October 2005 (2005-10-30), pages 162 - 172, XP005106049, ISSN: 0022-1759
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 2007028380 A1 20070315; AU 2006289514 A1 20070315; CA 2621789 A1 20070315; CN 101292159 A 20081022; EP 1922545 A1 20080521; JP 2009506780 A 20090219; RU 2008113383 A 20091020; RU 2416797 C2 20110420; US 2009220931 A1 20090903
DOCDB simple family (application)
DE 2006001604 W 20060908; AU 2006289514 A 20060908; CA 2621789 A 20060908; CN 200680039422 A 20060908; EP 06791374 A 20060908; JP 2008529467 A 20060908; RU 2008113383 A 20060908; US 6636506 A 20060908