EP 1928468 A4 20101208 - ESTRIOL THERAPY FOR AUTOIMMUNE AND NEURODEGENERATIVE DISEASES AND DISORDERS
Title (en)
ESTRIOL THERAPY FOR AUTOIMMUNE AND NEURODEGENERATIVE DISEASES AND DISORDERS
Title (de)
ÖSTRIOL-THERAPIE GEGEN AUTOIMMUNKRANKHEITEN UND NEURODEGENERATIVE ERKRANKUNGEN UND STÖRUNGEN
Title (fr)
THERAPIE PAR ESTRIOL POUR MALADIES ET TROUBLES NEURODEGENERATIFS ET AUTOIMMUNS
Publication
Application
Priority
- US 2006037259 W 20060926
- US 72097105 P 20050926
- US 83352706 P 20060726
Abstract (en)
[origin: WO2007038435A2] The present invention discloses administering steroid hormones to mammals to treat autoimmune related diseases, including post-partum auto immune diseases) and more particularly. Most preferably the invention uses estrogens, estranges, estriol or estrogen receptor active agents to prevent or ameliorate clinical symptoms of these ThI -mediated (cell-mediated) autoimmune diseases known to either have an initial onset following the birth of a child or which are exacerbated in patients in the post¬ partum period.
IPC 8 full level
G01N 33/00 (2006.01); A61K 31/565 (2006.01); A61K 31/566 (2006.01); A61K 31/568 (2006.01); A61K 45/06 (2006.01)
CPC (source: EP)
A61K 31/56 (2013.01); A61P 5/16 (2017.12); A61P 17/06 (2017.12); A61P 25/00 (2017.12); A61P 29/00 (2017.12); A61P 31/04 (2017.12); A61P 37/06 (2017.12); A61P 43/00 (2017.12)
Citation (search report)
- [X] US 5554601 A 19960910 - SIMPKINS JAMES W [US], et al
- [X] US 2001016325 A1 20010823 - MOBLEY WILLIAM C [US], et al
- [X] WO 9708188 A1 19970306 - ASTRA AB [SE], et al
- [X] OFFNER, HALINA: "Neuroimmunoprotective effects of estrogen and derivatives in experimental autoimmune encephalomyelitis: Therapeutic implications for multiple sclerosis", JOURNAL OF NEUROSCIENCE RESEARCH ( 2004 ), 78(5), 603-624 CODEN: JNREDK; ISSN: 0360-4012, 28 October 2004 (2004-10-28), XP002605593
- [XY] SAMANTHA S SOLDAN ET AL: "Immune modulation in multiple sclerosis patients treated with the pregnancy hormone estriol", JOURNAL OF IMMUNOLOGY, AMERICAN ASSOCIATION OF IMMUNOLOGISTS, US, vol. 171, no. 11, 1 December 2003 (2003-12-01), pages 6267 - 6268, XP008126547, ISSN: 0022-1767
- [X] RATKAY L G ET AL: "Evaluation of a model for post-partum arthritis and the role of oestrogen in prevention of MRL-lpr associated rheumatic conditions", CLINICAL AND EXPERIMENTAL IMMUNOLOGY, vol. 98, no. 1, 1994, pages 52 - 59, XP002606112, ISSN: 0009-9104
- [X] LIISA A M GALEA ET AL: "Estradiol alleviates depressive-like symptoms in novel animal model of post-partum depression", BEHAVIOURAL BRAIN RESEARCH, ELSEVIER, AMSTERDAM, NL LNKD- DOI:10.1016/S0166-4328(01)00170-X, vol. 122, no. 1, 1 January 2001 (2001-01-01), pages 1 - 9, XP008082590, ISSN: 0166-4328
- [Y] EL-ETR M ET AL: "Steroid hormones in multiple sclerosis", JOURNAL OF NEUROLOGICAL SCIENCES, ELSEVIER SCIENTIFIC PUBLISHING CO, AMSTERDAM, NL LNKD- DOI:10.1016/J.JNS.2005.03.004, vol. 233, no. 1-2, 15 June 2005 (2005-06-15), pages 49 - 54, XP004932279, ISSN: 0022-510X
- See references of WO 2007038435A2
Citation (examination)
- ANSAR AHMED S ET AL: "The effects of female sex steroids on the development of autoimmune thyroiditis in thymectomized and irradiated rats.", CLINICAL AND EXPERIMENTAL IMMUNOLOGY NOV 1983 LNKD- PUBMED:6360435, vol. 54, no. 2, November 1983 (1983-11-01), pages 351 - 358, ISSN: 0009-9104
- MURASE JENNY E ET AL: "Hormonal effect on psoriasis in pregnancy and post partum.", ARCHIVES OF DERMATOLOGY MAY 2005 LNKD- PUBMED:15897382, vol. 141, no. 5, May 2005 (2005-05-01), pages 601 - 606, ISSN: 0003-987X
- CHAN C-C ET AL: "A correlation of pregnancy term, disease activity, serum female hormones, and cytokines in uveitis.", THE BRITISH JOURNAL OF OPHTHALMOLOGY DEC 2004 LNKD- PUBMED:15548800, vol. 88, no. 12, December 2004 (2004-12-01), pages 1506 - 1509, ISSN: 0007-1161
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 2007038435 A2 20070405; WO 2007038435 A3 20070628; AU 2006294826 A1 20070405; CA 2623905 A1 20070405; EP 1928468 A2 20080611; EP 1928468 A4 20101208; JP 2009510070 A 20090312
DOCDB simple family (application)
US 2006037259 W 20060926; AU 2006294826 A 20060926; CA 2623905 A 20060926; EP 06815340 A 20060926; JP 2008533482 A 20060926