EP 1928826 B1 20130424 - SULPHONYLPYRROLE HYDROCHLORIDE SALTS AS HISTONE DEACETYLASES INHIBITORS
Title (en)
SULPHONYLPYRROLE HYDROCHLORIDE SALTS AS HISTONE DEACETYLASES INHIBITORS
Title (de)
SULFONYLPYRROLHYDROCHLORIDSALZE ALS INHIBITOREN VON HISTONDEACETYLASEN
Title (fr)
SELS DE CHLORHYDRATE DE SULFONYLPYRROLE COMME INHIBITEURS DE L'HISTONE DEACETYLASE
Publication
Application
Priority
- EP 2006066189 W 20060908
- EP 05108716 A 20050921
- EP 06778423 A 20060908
Abstract (en)
[origin: WO2007039403A1] Compounds of formula I, in which R1, R2, R3, R4, R5, R6 and R7 have the meanings indicated in the description, as well as salts thereof are novel effective HDAC inhibitors. In more detail, this invention refers to salts of a compound selected from (E)-(E)-N-hydroxy-3-(1-[4-(([2-(1H-indol-2yl)-ethyl]-methyl-amino)-methyl)-benzene sulfonyl]-1H-pyrrol-3-yl)-acrylamide, (E)-3-[1-(4-dimetylaminomethyl-benzenesulfonyl)-1H-pyrrol-3-yl]-N-hydroxy-acrylamide, and (E)-N-hydroxy-3-[1-(5-pyridin-2-yl-thiophene-2-sulfonyl)-1H-pyrrol-3-yl]-acrylamide with hydrochloric acid, their hydrates and to crystalline forms of these salts and hydrates.
IPC 8 full level
C07D 207/48 (2006.01); A61K 31/40 (2006.01)
CPC (source: EP KR US)
A61K 31/40 (2013.01 - KR); A61P 35/00 (2017.12 - EP); A61P 35/02 (2017.12 - EP); A61P 43/00 (2017.12 - EP); C07D 207/48 (2013.01 - EP KR US)
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR
Designated extension state (EPC)
AL BA HR MK RS
DOCDB simple family (publication)
WO 2007039403 A1 20070412; AR 055647 A1 20070829; AU 2006298881 A1 20070412; BR PI0616040 A2 20110607; CA 2622670 A1 20070412; CN 101287706 A 20081015; EA 018698 B1 20131030; EA 200800791 A1 20090428; EP 1928826 A1 20080611; EP 1928826 B1 20130424; IL 189781 A0 20080807; JP 2009508825 A 20090305; JP 5305909 B2 20131002; KR 101314158 B1 20131004; KR 20080046730 A 20080527; NO 20081796 L 20080417; NZ 566073 A 20110826; TW 200745027 A 20071216; TW I382971 B 20130121; US 2009297473 A1 20091203; US 8188138 B2 20120529; ZA 200801351 B 20090930
DOCDB simple family (application)
EP 2006066189 W 20060908; AR P060104134 A 20060921; AU 2006298881 A 20060908; BR PI0616040 A 20060908; CA 2622670 A 20060908; CN 200680034599 A 20060908; EA 200800791 A 20060908; EP 06778423 A 20060908; IL 18978108 A 20080226; JP 2008530491 A 20060908; KR 20087008939 A 20060908; NO 20081796 A 20080414; NZ 56607306 A 20060908; TW 95135002 A 20060921; US 99201806 A 20060908; ZA 200801351 A 20080208