EP 1929003 A2 20080611 - REAGENTS FOR THE DETECTION OF PROTEIN PHOSPHORYLATION IN CARCINOMA SIGNALING PATHWAYS
Title (en)
REAGENTS FOR THE DETECTION OF PROTEIN PHOSPHORYLATION IN CARCINOMA SIGNALING PATHWAYS
Title (de)
REAGENTIEN ZUM NACHWEIS VON PROTEINPHOSPHORYLIERUNG IN KARZINOM-SIGNALWEGEN
Title (fr)
REACTIFS DE DETECTION DE PHOSPORYLATION PROTEINIQUE DANS DES VOIES DE SIGNALISATION DE CARCINOME
Publication
Application
Priority
- US 2006033991 W 20060831
- US 71304105 P 20050831
Abstract (en)
[origin: WO2007027867A2] The invention discloses nearly 474 novel phosphorylation sites identified in signal transduction proteins and pathways underlying human carcinoma, and provides phosphorylation-site specific antibodies and heavy-isotope labeled peptides (AQUA peptides) for the selective detection and quantification of these phosphorylated sites/proteins, as well as methods of using the reagents for such purpose. Among the phosphorylation sites identified are sites occurring in the following protein types: Kinase, Adaptor/Scaffold proteins, Phosphatase, G protein Regulator/Guanine Nucleotide Exchange Factors/GTPase Activating Proteins, Cytoskeleton Proteins, DNA Binding Proteins, Phospholipase, Receptor Proteins, Enzymes, DNA Repair/Replication Proteins, Adhesion Proteins, and Proteases , as well as other protein types.
IPC 8 full level
C12N 9/12 (2006.01)
CPC (source: EP)
C07B 59/008 (2013.01); C07K 16/30 (2013.01); C07K 16/44 (2013.01); C12Q 1/42 (2013.01); C12Q 1/485 (2013.01); G01N 33/6872 (2013.01)
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR
Designated extension state (EPC)
AL BA HR MK RS
DOCDB simple family (publication)
WO 2007027867 A2 20070308; WO 2007027867 A3 20071221; EP 1929003 A2 20080611; EP 1929003 A4 20090429; EP 2182057 A1 20100505
DOCDB simple family (application)
US 2006033991 W 20060831; EP 06814000 A 20060831; EP 10151010 A 20060831