EP 1934614 A4 20100804 - REAGENTS FOR THE DETECTION OF PROTEIN PHOSPHORYLATION IN CARCINOMA SIGNALING PATHWAYS
Title (en)
REAGENTS FOR THE DETECTION OF PROTEIN PHOSPHORYLATION IN CARCINOMA SIGNALING PATHWAYS
Title (de)
REAGENTIEN ZUM NACHWEIS VON PROTEINPHOSPHORYLIERUNG IN KARZINOM-SIGNALWEGEN
Title (fr)
REACTIFS DE DETECTION DE LA PHOSPHORYLATION PROTEINIQUE DANS LA VOIE DE SIGNALISATION DE CARCINOME
Publication
Application
Priority
- US 2006034063 W 20060831
- US 71299705 P 20050831
Abstract (en)
[origin: WO2007027916A2] The invention discloses nearly (443) novel phosphorylation sites identified in signal transduction proteins and pathways underlying human carcinoma, and provides phosphorylation-site specific antibodies and heavy-isotope labeled peptides (AQUA peptides) for the selective detection and quantification of these phosphorylated sites/proteins, as well as methods of using the reagents for such purpose. Among the phosphorylation sites identified are sites occurring in the following protein types: Protein kinases (including Serine/Threonine dual specificity, and Tyrosine kinases), Adaptor/Scaffold proteins, Transcription factors, Phospoatases, Tumor supressors, Ubiquitin conjugating system proteins, Translation initiation complex proteins, RNA binding proteins, Apoptosis proteins, Adhesion proteins, G protein regulators/ GTPase activating protein/ Guanine nucleotide exchange factor proteins, and DNA binding/replication/repair proteins, as well as other protein types.
IPC 8 full level
C07K 16/32 (2006.01)
CPC (source: EP)
C07K 14/47 (2013.01); C07K 14/4748 (2013.01); C07K 16/44 (2013.01); G01N 33/57484 (2013.01); G01N 33/60 (2013.01); G01N 33/6812 (2013.01); G01N 33/6842 (2013.01)
Citation (search report)
- [Y] US 6924361 B1 20050802 - LAUDANO ANDREW PETER [US], et al
- [YD] US 2003044848 A1 20030306 - RUSH JOHN [US], et al
- [Y] WO 2004055519 A2 20040701 - HOFFMANN LA ROCHE [CH], et al
- [A] JAWHARI AIDA U ET AL: "Fascin, an actin-bundling protein, modulates colonic epithelial cell invasiveness and differentiation in vitro.", AMERICAN JOURNAL OF PATHOLOGY, vol. 162, no. 1, January 2003 (2003-01-01), pages 69 - 80, XP002587645, ISSN: 0002-9440
- [A] ONO SHOICHIRO ET AL: "Identification of an actin binding region and a protein kinase C phosphorylation site on human fascin", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 272, no. 4, 1997, pages 2527 - 2533, XP002587646, ISSN: 0021-9258
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 2007027916 A2 20070308; WO 2007027916 A9 20090430; EP 1934614 A2 20080625; EP 1934614 A4 20100804
DOCDB simple family (application)
US 2006034063 W 20060831; EP 06802734 A 20060831