EP 1937647 A1 20080702 - CONDENSED PYRAZOLE DERIVATIVES AS PPAR AGONISTS II
Title (en)
CONDENSED PYRAZOLE DERIVATIVES AS PPAR AGONISTS II
Title (de)
KONDENSIERTE PYRAZOLDERIVATE ALS PPAR-AGONISTEN II
Title (fr)
DERIVES DE PYRAZOLE CONDENSES UTILISES COMME AGONISTES II DU RECEPTEUR PPAR
Publication
Application
Priority
- GB 2006003608 W 20060928
- GB 0519874 A 20050929
- GB 0614578 A 20060721
Abstract (en)
[origin: WO2007036727A1] The invention discloses compounds of formula (I) wherein: R is a carboxylic acid or a derivative thereof; R<SUP>1</SUP> and R<SUP>2</SUP> are independently H or alkyl, or together R<SUP>1</SUP> and R<SUP>2</SUP> form an alkylene group; L<SUP>1</SUP> is a single bond, NH, NCH<SUB>3</SUB>, O, S, CH<SUB>2</SUB> or CH, wherein when L<SUP>1</SUP> is CH the dashed line indicates a double bond and R<SUP>2</SUP> is absent, otherwise the dashed line is a single bond; R<SUP>8</SUP> and R<SUP>9</SUP> are independently H, halo, alkyl or alkoxy; L<SUP>2</SUP> is O or S; L<SUP>3</SUP> is CH<SUB>2</SUB> or CH<SUB>2</SUB>CH<SUB>2</SUB>; R<SUP>10</SUP> and R<SUP>11</SUP> are independently H, halo, CF<SUB>3</SUB>, OCF<SUB>3</SUB>, alkyl or alkoxy; Y<SUP>1</SUP> is CH or N; Y<SUP>2</SUP> is CH or N; and R<SUP>12</SUP> and R<SUP>13</SUP> are independently H, halo, CF<SUB>3</SUB>, OCF<SUB>3</SUB>, alkyl or alkoxy; or a pharmaceutically acceptable derivative thereof, useful for treating disorders mediated by peroxisome-proliferator-activated receptor (PPAR) subtype d (PPARd). The compounds of the invention are therefore useful in the treatment of metabolic syndrome, obesity, type-II diabetes, dyslipidemia, wound healing, inflammation, neurodegenerative disorders and multiple sclerosis.
IPC 8 full level
C07D 231/56 (2006.01); A61K 31/416 (2006.01); A61K 31/437 (2006.01); A61P 3/00 (2006.01); C07D 471/04 (2006.01)
CPC (source: EP)
A61P 3/00 (2017.12); A61P 3/04 (2017.12); A61P 3/06 (2017.12); A61P 3/10 (2017.12); A61P 9/10 (2017.12); A61P 9/12 (2017.12); A61P 11/00 (2017.12); A61P 17/02 (2017.12); A61P 19/02 (2017.12); A61P 25/00 (2017.12); A61P 25/28 (2017.12); A61P 29/00 (2017.12); A61P 35/00 (2017.12); A61P 43/00 (2017.12); C07D 231/56 (2013.01); C07D 471/04 (2013.01)
Citation (search report)
See references of WO 2007036727A1
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 2007036727 A1 20070405; AU 2006296381 A1 20070405; CA 2624176 A1 20070405; EP 1937647 A1 20080702; JP 2009510042 A 20090312
DOCDB simple family (application)
GB 2006003608 W 20060928; AU 2006296381 A 20060928; CA 2624176 A 20060928; EP 06779567 A 20060928; JP 2008532870 A 20060928