EP 1937827 A4 20090218 - ANTIBODIES AND THEIR USE IN THE TREATMENT, PREVENTION AND DIAGNOSIS OF A DISEASE ASSOCIATED WITH SOD1 ABNORMALITIES
Title (en)
ANTIBODIES AND THEIR USE IN THE TREATMENT, PREVENTION AND DIAGNOSIS OF A DISEASE ASSOCIATED WITH SOD1 ABNORMALITIES
Title (de)
ANTIKÖRPER UND IHRE VERWENDUNG BEI DER BEHANDLUNG, VORBEUGUNG UND DIAGNOSE EINER MIT SOD1-ANOMALIEN ASSOZIIERTEN KRANKHEIT
Title (fr)
ANTICORPS ET LEUR UTILISATION DANS LE TRAITEMENT, LA PREVENTION ET LE DIAGNOSTIC D'UNE MALADIE ASSOCIEE A DES ANOMALIES DE SOD1
Publication
Application
Priority
- CA 2006001444 W 20060831
- US 71240005 P 20050831
Abstract (en)
[origin: US9266963B2] The present invention concerns an antibody which specifically binds to an abnormal superoxide dismutase 1 (SOD1), and which neutralizes its pathologic effect when administered to an animal such as a human. The antibody of the invention is a monoclonal antibody produced by hybridoma cell lines deposited with the International Depositary Authority of Canada on Aug. 29, 2006 under accession numbers ADI-290806-01, ADI-290806-02 and ADS-290806-03. The present invention also concerns the use of the antibody of the invention in the treatment, prevention and diagnosis of neurodegenerative diseases such as Amyotrophic lateral sclerosis, Parkinson and Alzheimer in an animal such as a human.
IPC 8 full level
C07K 16/40 (2006.01); A61K 39/395 (2006.01); A61P 25/28 (2006.01); C12N 5/18 (2006.01); C12N 9/04 (2006.01); C12N 15/53 (2006.01); C12P 21/08 (2006.01); G01N 33/53 (2006.01)
CPC (source: EP US)
A61P 21/02 (2018.01 - EP); A61P 25/16 (2018.01 - EP); A61P 25/28 (2018.01 - EP); C07K 16/40 (2013.01 - EP US); G01N 33/573 (2013.01 - US); A61K 2039/505 (2013.01 - EP US); C07K 2317/76 (2013.01 - US); G01N 2333/90283 (2013.01 - US); G01N 2800/28 (2013.01 - US); G01N 2800/2821 (2013.01 - EP US); G01N 2800/2835 (2013.01 - EP US)
Citation (search report)
- [X] WO 2005019828 A1 20050303 - CASHMAN NEIL [CA], et al
- [X] FUJIWARA NORIKO ET AL: "Different immunoreactivity against monoclonal antibodies between wild-type and mutant copper/zinc superoxide dismutase linked to amyotrophic lateral sclerosis", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 280, no. 6, 11 February 2005 (2005-02-11), pages 5061 - 5070, XP002508783, ISSN: 0021-9258
- [T] URUSHITANI MAKOTO ET AL: "Therapeutic effects of immunization with mutant superoxide dismutase in mice models of amyotrophic lateral sclerosis", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 104, no. 7, February 2007 (2007-02-01), pages 2495 - 2500, XP002508784, ISSN: 0027-8424
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR
Designated extension state (EPC)
AL BA HR MK RS
DOCDB simple family (publication)
WO 2007025385 A1 20070308; AT E526345 T1 20111015; CA 2620351 A1 20070308; CA 2620351 C 20150421; DK 1937827 T3 20120123; EP 1937827 A1 20080702; EP 1937827 A4 20090218; EP 1937827 B1 20110928; ES 2374102 T3 20120213; JP 2009507475 A 20090226; JP 5242396 B2 20130724; US 2009068194 A1 20090312; US 2014341927 A1 20141120; US 8759029 B2 20140624; US 9266963 B2 20160223
DOCDB simple family (application)
CA 2006001444 W 20060831; AT 06790622 T 20060831; CA 2620351 A 20060831; DK 06790622 T 20060831; EP 06790622 A 20060831; ES 06790622 T 20060831; JP 2008528307 A 20060831; US 201414288374 A 20140527; US 6540306 A 20060831