EP 1940458 A4 20100303 - COMPOSITIONS FOR AND METHODS OF GRANZYME B INHIBITION
Title (en)
COMPOSITIONS FOR AND METHODS OF GRANZYME B INHIBITION
Title (de)
ZUSAMMENSETZUNGEN FÜR UND VERFAHREN ZUR HEMMUNG VON GRANZYME B
Title (fr)
COMPOSITIONS ET PROCEDES D'INHIBITION DU GRANZYME B
Publication
Application
Priority
- CA 2006001582 W 20060926
- US 72179905 P 20050929
Abstract (en)
[origin: WO2007036028A1] The present invention is related to the discovery that serpina3n, a secreted protein, binds to and inhibits granzyme B activity. The invention thus provides cells that include a polynucleotide encoding a granzyme B inhibitory serpin, pharmaceutical compositions including a granzyme B inhibitory serpin or a polynucleotide encoding a granzyme B inhibitory serpin, methods for treating a patient in need of immunosuppression by administration of a granzyme B inhibitory serpin, and methods of transplanting cells (e.g., islet cells) expressing a granzyme B inhibitory serpin.
IPC 8 full level
A61K 38/57 (2006.01); A01K 67/027 (2006.01); A61K 31/7088 (2006.01); A61K 35/14 (2006.01); A61K 35/34 (2015.01); A61K 35/39 (2015.01); A61K 48/00 (2006.01); A61P 37/06 (2006.01)
CPC (source: EP US)
A01K 67/0275 (2013.01 - EP US); A61K 31/7088 (2013.01 - EP US); A61K 35/34 (2013.01 - EP US); A61K 35/39 (2013.01 - EP US); A61K 35/60 (2013.01 - EP US); A61K 38/28 (2013.01 - EP US); A61P 3/10 (2017.12 - EP); A61P 9/00 (2017.12 - EP); A61P 19/02 (2017.12 - EP); A61P 25/00 (2017.12 - EP); A61P 29/00 (2017.12 - EP); A61P 37/00 (2017.12 - EP); A61P 37/06 (2017.12 - EP); A61P 43/00 (2017.12 - EP); C07K 14/8121 (2013.01 - EP US); C12N 9/6467 (2013.01 - EP US); C12N 15/8509 (2013.01 - EP US); A01K 2217/05 (2013.01 - EP US); A01K 2227/108 (2013.01 - EP US); A01K 2227/40 (2013.01 - EP US); A01K 2267/02 (2013.01 - EP US); A01K 2267/025 (2013.01 - EP US); A61K 48/00 (2013.01 - EP US)
C-Set (source: EP US)
Citation (search report)
- [XI] WO 9527055 A1 19951012 - UNIV PENNSYLVANIA [US]
- [XPI] WO 2006091773 A2 20060831 - UNIV CHICAGO [US], et al
- [I] CYTOKINE, vol. 11, no. 11, November 1999 (1999-11-01), pages 856 - 862, XP002564094, ISSN: 1043-4666
- [I] KIDNEY INTERNATIONAL, vol. 66, no. 4, October 2004 (2004-10-01), pages 1417 - 1422, XP002564095, ISSN: 0085-2538
- [XAI] NILSSON L N G ET AL: "Alpha1-antichymotrypsin promotes beta-sheet amyloid plaque deposition in a transgenic mouse model of Alzheimer's disease", JOURNAL OF NEUROSCIENCE, NEW YORK, NY, US, vol. 21, no. 5, 1 March 2001 (2001-03-01), pages 1444 - 1451, XP002215417, ISSN: 0270-6474
- [T] JOURNAL OF IMMUNOLOGY, vol. 177, no. 8, October 2006 (2006-10-01), pages 5051 - 5058, XP002564096, ISSN: 0022-1767
- See references of WO 2007036028A1
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 2007036028 A1 20070405; WO 2007036028 A9 20070705; AU 2006297036 A1 20070405; CA 2623957 A1 20070405; EP 1940458 A1 20080709; EP 1940458 A4 20100303; JP 2009509979 A 20090312; US 2007104699 A1 20070510; US 2011083201 A1 20110407
DOCDB simple family (application)
CA 2006001582 W 20060926; AU 2006297036 A 20060926; CA 2623957 A 20060926; EP 06790747 A 20060926; JP 2008532546 A 20060926; US 52737306 A 20060926; US 87657410 A 20100907