EP 1941036 A1 20080709 - NOVEL TYROSINASE-SPECIFIC ANTIGENIC OLIGONUCLEOTIDES AS DEPIGMENTING AGENTS
Title (en)
NOVEL TYROSINASE-SPECIFIC ANTIGENIC OLIGONUCLEOTIDES AS DEPIGMENTING AGENTS
Title (de)
NEUE TYROSINASE-SPEZIFISCHE ANTIGENE OLIGONUKLEOTIDE ALS DEPIGMENTIERUNGSMITTEL
Title (fr)
NOUVEAUX OLIGONUCLÉOTIDES ANTI-GÈNES SPÉCIFIQUES DE LA TYROSINASE COMME AGENTS DÉPIGMENTANTS
Publication
Application
Priority
- EP 2006065902 W 20060901
- FR 0508981 A 20050901
Abstract (en)
[origin: FR2890074A1] An oligonucleotide inhibitor of tyrosinase gene expression comprising a sequence of 15-25 nucleotides including a specific 21 nucleotide sequence (SEQ ID NO:1) which hybridizes to the human tyrosinase gene by Hoogsteen pairing to form a triple helix structure, is new. An oligonucleotide inhibitor of tyrosinase gene expression comprising a sequence of 15-25 nucleotides including a specific 21 nucleotide sequence (SEQ ID NO:1) which hybridizes to the human tyrosinase gene by Hoogsteen pairing to form a triple helix structure, is new. Independent claims are included for: (1) a cosmetic or dermatological composition comprising the oligonucleotide inhibitor; and (2) cosmetic process of treatment for depigmentation or to bleach the skin or hair, comprising application of the composition on pigmented zone of the skin or pilous of hair and optional repetition of the operation until the appearance of depigmented effect. 5'-C*TTC*TC*TC*TTTTTC*C*TTTTTC*-3' sequence (SEQ ID No. 1), where C* is a 5-methyl-cytosine ACTIVITY : Dermatological. MECHANISM OF ACTION : Tyrosinase expression inhibitor. The ability of the oligonucleotide to inhibit the expression of human tyrosinase was tested using reverse transcriptase polymerase chain reaction. The results showed that the LNA oligonucleotide exhibited an inhibition of 49%.
IPC 8 full level
A61K 31/7088 (2006.01); A61P 17/00 (2006.01); A61Q 17/04 (2006.01); A61Q 19/02 (2006.01); C12N 15/113 (2010.01)
CPC (source: EP KR US)
A61K 8/606 (2013.01 - EP US); A61K 31/7088 (2013.01 - KR); A61P 17/00 (2017.12 - EP); A61Q 19/02 (2013.01 - EP US); C12N 15/11 (2013.01 - KR); C12N 15/1137 (2013.01 - EP US); C12Y 114/18001 (2013.01 - EP US); A61Q 17/04 (2013.01 - EP US); C12N 2310/15 (2013.01 - EP US); C12N 2310/3231 (2013.01 - EP US); C12N 2310/3341 (2013.01 - EP US)
Citation (search report)
See references of WO 2007026009A1
Designated contracting state (EPC)
DE FR GB IT
DOCDB simple family (publication)
FR 2890074 A1 20070302; FR 2890074 B1 20071123; EP 1941036 A1 20080709; JP 2009506763 A 20090219; JP 5208740 B2 20130612; KR 101418934 B1 20140715; KR 20080074094 A 20080812; US 2010047192 A1 20100225; WO 2007026009 A1 20070308
DOCDB simple family (application)
FR 0508981 A 20050901; EP 06793134 A 20060901; EP 2006065902 W 20060901; JP 2008528527 A 20060901; KR 20087007492 A 20060901; US 99131706 A 20060901