EP 1942887 A1 20080716 - TACROLIMUS COMBINATION PRODUCTS
Title (en)
TACROLIMUS COMBINATION PRODUCTS
Title (de)
TACROLIMUS-KOMBINATIONSPRODUKTE
Title (fr)
PRODUITS COMBINÉS CONTENANT DU TACROLIMUS
Publication
Application
Priority
- DK 2006000569 W 20061009
- DK PA200501411 A 20051007
Abstract (en)
[origin: WO2007042037A1] The present invention relates to a pharmaceutical composition comprising tacrolimus or an analogue thereof and a substance being a substrate for CYP3A4 and/or P-glycoprotein, oral solid dosage forms comprising the pharmaceutical composition such as tablets, methods for preparing the pharmaceutical composition and oral dosage forms and use of the pharmaceutical composition for preparing a medicament. The substance being a substrate for CYP3A4 and/or P-glycoprotein is preferably cyclosporine A. The invention further relates to treatment of a patient in need thereof by coadministration of the combination according to the invention. In a further aspect, the invention relates to the above combination further comprising a CYP3A4 inhibitor compound, preferably a compound naturally occurring in citrus juice, for example grapefruit juice, preferably a spiro ortho ester compound.
IPC 8 full level
A61K 31/357 (2006.01); A61K 31/365 (2006.01); A61K 31/436 (2006.01); A61K 31/496 (2006.01); A61K 38/13 (2006.01)
CPC (source: EP US)
A61K 9/2013 (2013.01 - EP US); A61K 9/2018 (2013.01 - EP US); A61K 9/2027 (2013.01 - EP US); A61K 9/209 (2013.01 - EP US); A61K 31/357 (2013.01 - EP US); A61K 31/365 (2013.01 - EP US); A61K 31/436 (2013.01 - EP US); A61K 31/496 (2013.01 - EP US); A61K 38/13 (2013.01 - EP US); A61K 45/06 (2013.01 - EP US); A61P 37/00 (2017.12 - EP)
Citation (search report)
See references of WO 2007042037A1
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR
Designated extension state (EPC)
AL BA HR MK RS
DOCDB simple family (publication)
WO 2007042037 A1 20070419; CA 2624825 A1 20070419; EP 1942887 A1 20080716; US 2009011013 A1 20090108
DOCDB simple family (application)
DK 2006000569 W 20061009; CA 2624825 A 20061009; EP 06791457 A 20061009; US 8908206 A 20061009