EP 1945653 A4 20120314 - IMMUNOSTIMULATORY PROPERTIES OF OLIGONUCLEOTIDE-BASED COMPOUNDS COMPRISING MODIFIED IMMUNOSTIMULATORY DINUCLEOTIDES
Title (en)
IMMUNOSTIMULATORY PROPERTIES OF OLIGONUCLEOTIDE-BASED COMPOUNDS COMPRISING MODIFIED IMMUNOSTIMULATORY DINUCLEOTIDES
Title (de)
IMMUNSTIMULIERENDE EIGENSCHAFTEN VON VERBINDUNGEN AUF OLIGONUKLEOTIDBASIS, DIE MODIFIZIERTE IMMUNSTIMULIERENDE DINUKLEOTIDE ENTHALTEN
Title (fr)
PROPRIETES IMMUNOSTIMULATRICES DE COMPOSES A BASE D'OLIGONUCLEOTIDES COMPRENANT DES DINUCLEOTIDES IMMUNOSTIMULATEURS MODIFIES
Publication
Application
Priority
US 2005040215 W 20051107
Abstract (en)
[origin: WO2007055682A2] The invention relates to the therapeutic use of oligonucleotides as immunostimulatory agents in immunotherapy applications. More particularly, the invention provides an immunostimulatory oligonucleotides for use in methods for generating an immune response or for treating a patient in need of immunostimulation. The immunostimulatory oligonucleotides of the invention preferably comprise novel purines. The immunostimulatory oligonucleotides according to the invention further comprise at least two oligonucleotides linked at their 3' ends, internucleoside linkages or functionalized nucleobase or sugar to a non-nucleotidic linker, at least one of the oligonucleotides being an immunostimulatory oligonucleotide and having an accessible 5' end.
IPC 8 full level
C07H 21/04 (2006.01)
CPC (source: EP)
A61P 11/04 (2017.12); A61P 11/06 (2017.12); A61P 17/00 (2017.12); A61P 29/00 (2017.12); A61P 31/00 (2017.12); A61P 35/00 (2017.12); A61P 37/02 (2017.12); A61P 37/08 (2017.12); C12N 15/117 (2013.01); C12N 2310/17 (2013.01); C12N 2310/318 (2013.01); C12N 2310/321 (2013.01); C12N 2310/33 (2013.01)
Citation (search report)
- [A] WO 2004064782 A2 20040805 - HYBRIDON INC [US]
- [A] YU DONG ET AL: "'Immunomers': Novel 3'-3'-linked CpG oligodeoxyribonucleotides as potent immunomodulatory agents", NUCLEIC ACIDS RESEARCH, OXFORD UNIVERSITY PRESS, SURREY, GB, vol. 30, no. 20, 15 October 2002 (2002-10-15), pages 4460 - 4469, XP002447831, ISSN: 0305-1048, DOI: 10.1093/NAR/GKF582
- [T] YU DONG ET AL: "Agonists of Toll-like receptor 9 containing synthetic dinucleotide motifs", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 50, no. 25, 11 August 2007 (2007-08-11), pages 6411 - 6418, XP002590545, ISSN: 0022-2623, [retrieved on 20071108], DOI: 10.1021/JM0708811
- See references of WO 2007055682A2
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 2007055682 A2 20070518; WO 2007055682 A8 20070802; AU 2005338050 A1 20070518; AU 2005338050 A8 20080703; AU 2005338050 B2 20120202; CA 2630118 A1 20070518; CN 101351469 A 20090121; EP 1945653 A2 20080723; EP 1945653 A4 20120314; JP 2009514525 A 20090409; MX 2008006004 A 20081001
DOCDB simple family (application)
US 2005040215 W 20051107; AU 2005338050 A 20051107; CA 2630118 A 20051107; CN 200580052483 A 20051107; EP 05851389 A 20051107; JP 2008538854 A 20051107; MX 2008006004 A 20051107