EP 1954243 A2 20080813 - A METHOD FOR PREPARING LIPOSOMES AND USES THEREOF
Title (en)
A METHOD FOR PREPARING LIPOSOMES AND USES THEREOF
Title (de)
VERFAHREN ZUR HERSTELLUNG VON LIPOSOMEN UND SEINE VERWENDUNGEN
Title (fr)
METHODE DE PREPARATION DE LIPOSOMES ET UTILISATIONS
Publication
Application
Priority
- IL 2006001229 W 20061026
- US 73004505 P 20051026
Abstract (en)
[origin: WO2007049278A2] The present invention provides a simplified and cost effective method preparing liposomes, the method comprising providing a dry liposome forming lipid or a dry mixture comprising a liposome forming lipid; dissolving the liposome forming lipid or said mixture comprising a liposome forming lipid of step (a) with a protic organic solvent to form a solution or dispersion of said lipid; and adding the solution or dispersion of step (b) to ions containing aqueous solution to form a liposome suspension; wherein the liposomes are capable of encapsulating an agent at a ratio between the agent and the liposome forming lipid being greater than 1.0. The method is characterized in that it does not involve drying the solution or dispersion to form a dry lipid film; and/or down-sizing liposomes in said liposome suspension to form small unilamellar vesicles (SUV). The thus formed liposomes may then be used for loading thereto an active agent, such as amphiphatic weak acid/base drugs.
IPC 8 full level
A61K 9/127 (2006.01)
CPC (source: EP)
A61K 9/127 (2013.01); A61K 9/1277 (2013.01)
Citation (search report)
See references of WO 2007049278A2
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 2007049278 A2 20070503; WO 2007049278 A3 20070913; AU 2006307460 A1 20070503; CA 2627657 A1 20070503; EP 1954243 A2 20080813; JP 2009513621 A 20090402
DOCDB simple family (application)
IL 2006001229 W 20061026; AU 2006307460 A 20061026; CA 2627657 A 20061026; EP 06809790 A 20061026; JP 2008537312 A 20061026