EP 1957540 B1 20120613 - BINDING POLYPEPTIDES AND USES THEREOF
Title (en)
BINDING POLYPEPTIDES AND USES THEREOF
Title (de)
BINDUNGSPOLYPEPTIDE UND VERWENDUNG DAVON
Title (fr)
POLYPEPTIDES DE LIAISON ET LEURS UTILISATIONS
Publication
Application
Priority
- US 2006046046 W 20061201
- US 74218505 P 20051202
- US 80555306 P 20060622
Abstract (en)
[origin: WO2007094842A2] The invention provides antibodies or antigen binding fragments thereof to DR5 and HER-2. The antibodies and/ or antigen binding fragments thereof comprise variant CDRs comprising highly restricted amino acid sequence diversity. The invention also provides these polypeptides as fusion polypeptides to heterologous polypeptides such as at least a portion of phage or viral coat proteins, tags and linkers. In addition, compositions and methods of use for treatment of cancer and immune related conditions are provided.
IPC 8 full level
C07K 16/32 (2006.01); C07K 16/28 (2006.01)
CPC (source: EP KR US)
A61P 1/04 (2017.12 - EP); A61P 1/16 (2017.12 - EP); A61P 7/00 (2017.12 - EP); A61P 11/00 (2017.12 - EP); A61P 13/08 (2017.12 - EP); A61P 13/12 (2017.12 - EP); A61P 15/00 (2017.12 - EP); A61P 17/00 (2017.12 - EP); A61P 19/02 (2017.12 - EP); A61P 29/00 (2017.12 - EP); A61P 35/00 (2017.12 - EP); A61P 35/02 (2017.12 - EP); A61P 37/00 (2017.12 - EP); A61P 37/02 (2017.12 - EP); A61P 43/00 (2017.12 - EP); C07K 16/005 (2013.01 - EP US); C07K 16/2878 (2013.01 - EP US); C07K 16/32 (2013.01 - EP KR US); C40B 30/04 (2013.01 - KR); C40B 40/08 (2013.01 - KR); G01N 33/574 (2013.01 - EP US); G01N 33/6857 (2013.01 - EP US); C07K 2317/24 (2013.01 - EP US); C07K 2317/55 (2013.01 - EP US); C07K 2317/565 (2013.01 - EP US); C07K 2317/92 (2013.01 - EP US); G01N 2333/70539 (2013.01 - EP US); G01N 2333/71 (2013.01 - EP US)
Citation (examination)
- WO 03087131 A2 20031023 - GENENTECH INC [US], et al
- SPIRIDON CAMELIA I ET AL: "Targeting multiple Her-2 epitopes with monoclonal antibodies results in improved antigrowth activity of a human breast cancer cell line in vitro and in vivo", CLINICAL CANCER RESEARCH, THE AMERICAN ASSOCIATION FOR CANCER RESEARCH, US, vol. 8, no. 6, 1 June 2002 (2002-06-01), pages 1720 - 1730, XP002389218, ISSN: 1078-0432
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 2007094842 A2 20070823; WO 2007094842 A3 20080228; AU 2006338198 A1 20070823; AU 2006338198 B2 20120426; CA 2631327 A1 20070823; CA 2631327 C 20151013; EP 1957540 A2 20080820; EP 1957540 B1 20120613; ES 2388932 T3 20121019; HK 1121470 A1 20090424; JP 2009518011 A 20090507; JP 5808070 B2 20151110; KR 101434682 B1 20140827; KR 20080077246 A 20080821; RU 2008126948 A 20100110; RU 2470941 C2 20121227; US 2007202552 A1 20070830; US 8957187 B2 20150217; ZA 200805045 B 20091230
DOCDB simple family (application)
US 2006046046 W 20061201; AU 2006338198 A 20061201; CA 2631327 A 20061201; EP 06849911 A 20061201; ES 06849911 T 20061201; HK 09101623 A 20090220; JP 2008543499 A 20061201; KR 20087016105 A 20061201; RU 2008126948 A 20061201; US 56612006 A 20061201; ZA 200805045 A 20080610