EP 1963330 A1 20080903 - DIMERS AND ADDUCTS OF 6-[SUBSTITUTED) PHENYL] TRIAZOLOPYRIMIDINES USEFUL AS ANTICANCER AGENTS
Title (en)
DIMERS AND ADDUCTS OF 6-[SUBSTITUTED) PHENYL] TRIAZOLOPYRIMIDINES USEFUL AS ANTICANCER AGENTS
Title (de)
DIMERE UND ADDUKTE VON 6-[SUBSTITUIERTEN) PHENYL]-TRIAZOLOPYRIMIDINEN ALS MITTEL GEGEN KREBS
Title (fr)
DIMERES ET PRODUITS D'ADDITION DE 6-[PHENYL (SUBSTITUE)] TRIAZOLOPYRIMIDINES UTILISABLES EN TANT QU'AGENTS ANTICANCEREUX
Publication
Application
Priority
- US 2006048013 W 20061215
- US 75116605 P 20051216
Abstract (en)
[origin: WO2007075465A1] Certain adducts and dinners of 6-[(substituted)phenyl]triazolopyrimidine compounds or pharmaceutically acceptable salts thereof, and compositions containing said compounds or pharmaceutically acceptable salts thereof, wherein said compounds are anti-cancer agents useful for the treatment of cancer in mammals, are disclosed. Also disclosed is a method of treating or inhibiting the growth of cancerous tumor cells and associated diseases in a mammal and a method for the treatment or prevention of cancerous tumors that express multiple drug resistance (MDR) or are resistant because of MDR, in a mammal in need thereof which method comprises administering to said mammal an effective amount of said compounds or pharmaceutically acceptable salts thereof. Also disclosed is a method of treating or inhibiting the growth of cancerous tumor cells and associated diseases in a mammal in need thereof by promotion of microtubule polymerization which comprises administering to said mammal an effective amount of said compounds and pharmaceutically acceptable salts thereof.
IPC 8 full level
C07D 487/04 (2006.01); A61K 31/519 (2006.01); A61P 35/04 (2006.01)
CPC (source: EP)
A61P 35/00 (2017.12); A61P 35/04 (2017.12); A61P 43/00 (2017.12); C07D 487/04 (2013.01)
Citation (search report)
See references of WO 2007075465A1
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 2007075465 A1 20070705; WO 2007075465 A8 20080529; AU 2006329862 A1 20070705; BR PI0619918 A2 20111025; CA 2633962 A1 20070705; CN 101370813 A 20090218; EP 1963330 A1 20080903; JP 2009519954 A 20090521
DOCDB simple family (application)
US 2006048013 W 20061215; AU 2006329862 A 20061215; BR PI0619918 A 20061215; CA 2633962 A 20061215; CN 200680052734 A 20061215; EP 06845599 A 20061215; JP 2008545859 A 20061215