EP 1966181 A2 20080910 - ANTHRANILIC ACID DERIVATIVES USEFUL IN TREATING INFECTION WITH HEPATITIS C VIRUS
Title (en)
ANTHRANILIC ACID DERIVATIVES USEFUL IN TREATING INFECTION WITH HEPATITIS C VIRUS
Title (de)
ANTHRANILSÄURE-DERIVATE ZUR BEHANDULNG VON INFEKTIONEN MIT HEPATITIS-C-VIRUS
Title (fr)
DÉRIVÉS DE L'ACIDE ANTHRANILIQUE UTILISABLES POUR LE TRAITEMENT D'UNE INFECTION PAR LE VIRUS DE L'HÉPATITE C
Publication
Application
Priority
- US 2006045950 W 20061201
- US 74177205 P 20051201
Abstract (en)
[origin: WO2008051244A2] The present invention is directed to compounds of formula (I): wherein R<SUP>1</SUP> is selected from the group consisting of -C(O)R and (a), wherein R<SUP>6</SUP> and R<SUP>7</SUP> are independently selected from H, alkyl, cycloalkyl, heterocycloalkyl, heteroaryl or aryl, any of which may be optionally substituted, G is selected from H or hydroxyl, Y is O, NH or S, X is selected from the group consisting of H, halo, alkyl, cycloalkyl, perfluoroalkyl, alkoxy, alkylthio, amino, alkylamino, dialkylamino, and CN, and n is 0, 1, 2 or 3, or a prodrug, a pharmaceutically acceptable salt, or a pharmaceutically active metabolite thereof. This invention is also directed to compositions containing compounds of the invention and methods of using both the inventive compounds and compositions thereof to treat or prevent Hepatitis C virus infection, or to inhibit replication of a Hepatitis C virus.
IPC 8 full level
C07D 317/66 (2006.01); A61K 31/36 (2006.01); A61P 31/12 (2006.01); C07C 235/24 (2006.01); C07C 237/04 (2006.01); C07C 251/48 (2006.01)
CPC (source: EP)
A61P 31/12 (2017.12); A61P 31/14 (2017.12); A61P 43/00 (2017.12); C07C 235/24 (2013.01); C07C 237/04 (2013.01); C07C 251/48 (2013.01); C07C 317/36 (2013.01); C07D 317/66 (2013.01)
Citation (search report)
See references of WO 2008051244A2
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR
Designated extension state (EPC)
AL BA HR MK RS
DOCDB simple family (publication)
WO 2008051244 A2 20080502; WO 2008051244 A3 20080717; AU 2006349612 A1 20080502; BR PI0619132 A2 20110913; CA 2631024 A1 20080502; CN 101336236 A 20081231; EP 1966181 A2 20080910; JP 2009519240 A 20090514
DOCDB simple family (application)
US 2006045950 W 20061201; AU 2006349612 A 20061201; BR PI0619132 A 20061201; CA 2631024 A 20061201; CN 200680051971 A 20061201; EP 06851777 A 20061201; JP 2008543479 A 20061201