Global Patent Index - EP 1967209 A4

EP 1967209 A4 20091111 - THERAPEUTIC AGENT FOR PROSTATE CANCER

Title (en)

THERAPEUTIC AGENT FOR PROSTATE CANCER

Title (de)

THERAPEUTISCHES MITTEL GEGEN PROSTATAKREBS

Title (fr)

AGENT THÉRAPEUTIQUE POUR LE CANCER DE LA PROSTATE

Publication

EP 1967209 A4 20091111 (EN)

Application

EP 06833196 A 20061124

Priority

  • JP 2006323392 W 20061124
  • JP 2005340050 A 20051125

Abstract (en)

[origin: EP1967209A1] The present inventors investigated the antitumor effects of anti-IL-6 receptor antibodies against prostate cancer. The result showed that the anti-IL-6 receptor antibodies had both in vivo and in vitro antitumor effects against prostate cancer. It was also revealed that the hPM1 antitumor effect is via IL-6 receptor.

IPC 8 full level

A61K 45/00 (2006.01); A61K 39/395 (2006.01); A61P 13/08 (2006.01); A61P 35/00 (2006.01)

CPC (source: EP KR US)

A61K 39/395 (2013.01 - KR); A61K 45/00 (2013.01 - KR); A61P 13/08 (2017.12 - EP); A61P 35/00 (2017.12 - EP); C07K 16/2866 (2013.01 - EP US); A61K 2039/505 (2013.01 - EP US)

Citation (search report)

  • [X] WO 2004071404 A2 20040826 - CENTOCOR INC [US], et al
  • [X] WO 2005107800 A1 20051117 - KIM KYUNG JIN [US], et al
  • [X] WO 2005044848 A1 20050519 - NAT CANCER CT [KR], et al
  • [X] BORSELLINO N ET AL: "Blocking signaling through the Gp130 receptor chain by interleukin-6 and oncostatin M inhibits PC-3 cell growth and sensitizes the tumor cells to etoposide and cisplatin-mediated cytotoxicity.", CANCER, vol. 85, no. 1, 1999, pages 134 - 144, XP002543275
  • [X] LEE SOO OK ET AL: "Interleukin-6 protects LNCaP cells from apoptosis induced by androgen deprivation through the Stat3 pathway.", THE PROSTATE, vol. 60, no. 3, 2004, pages 178 - 186, XP002543276
  • [X] DAVIES GAYNOR ET AL: "The HGF/SF antagonist NK4 reverses fibroblast- and HGF-induced prostate tumor growth and angiogenesis in vivo.", INTERNATIONAL JOURNAL OF CANCER, vol. 106, no. 3, 2003, pages 348 - 354, XP002543277
  • [X] XING Y; ET AL: "THE EFFECT OF INTERLEUKIN-6 ON THE PROLIFERATION OF PROSTATE CANCER CELLS IN VITRO AND THE MODULATION OF THIS PROCEDURE", JOURNAL OF TONGJI MEDICAL UNIVERSITY, vol. 21, no. 3, 2001, pages 225 - 227, XP008047142
  • [X] CULIG ZORAN ET AL: "Interleukin-6 regulates androgen receptor activity and prostate cancer cell growth.", MOLECULAR AND CELLULAR ENDOCRINOLOGY, vol. 197, no. 1-2, 2002, pages 231 - 238, XP002543278
  • [X] EDER IRIS E ET AL: "Targeting the androgen receptor in hormone-refractory prostate cancer--new concepts.", FUTURE ONCOLOGY, vol. 1, no. 1, February 2005 (2005-02-01), pages 93 - 101, XP002543279
  • [A] TRIKHA MOHIT ET AL: "Targeted anti-interleukin-6 monoclonal antibody therapy for cancer: a review of the rationale and clinical evidence.", CLINICAL CANCER RESEARCH, vol. 9, no. 13, 2003, pages 4653 - 4665, XP002543280
  • [A] PAULE B: "Reappraisal of the concept of hormone therapy in metastatic prostate cancer and implications for treatment", EUROPEAN UROLOGY, vol. 47, no. 6, June 2005 (2005-06-01), pages 729 - 735, XP004941460
  • See references of WO 2007061029A1

Designated contracting state (EPC)

AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR

DOCDB simple family (publication)

EP 1967209 A1 20080910; EP 1967209 A4 20091111; EP 1967209 B1 20120606; AR 057941 A1 20071226; JP WO2007061029 A1 20090507; KR 20080084818 A 20080919; TW 200803894 A 20080116; US 2009269335 A1 20091029; WO 2007061029 A1 20070531

DOCDB simple family (application)

EP 06833196 A 20061124; AR P060105200 A 20061124; JP 2006323392 W 20061124; JP 2007546491 A 20061124; KR 20087015187 A 20080623; TW 95143540 A 20061124; US 9464406 A 20061124