EP 1968935 A1 20080917 - SUBSTITUTED BIS(HETERO)AROMATIC N-ETHYLPROPIOLAMIDES AND USE THEREOF FOR PRODUCTION OF MEDICAMENTS
Title (en)
SUBSTITUTED BIS(HETERO)AROMATIC N-ETHYLPROPIOLAMIDES AND USE THEREOF FOR PRODUCTION OF MEDICAMENTS
Title (de)
SUBSTITUIERTE BIS(HETERO)AROMATISCHE N-ETHYLPROPIOLAMIDE UND IHRE VERWENDUNG ZUR HERSTELLUNG VON ARZNEIMITTELN
Title (fr)
BIS(HETERO) N-ETHYLPROPIOLAMIDES AROMATIQUES SUBSTITUES ET UTILISATION POUR LA FABRICATION DE MEDICAMENTS
Publication
Application
Priority
- EP 2006012480 W 20061222
- DE 102005062985 A 20051228
Abstract (en)
[origin: DE102005062985A1] Bis-aromatic substituted N-ethyl propiolamide derivatives (I) optionally as pure stereoisomers, particularly enantiomers or diastereomers, including racemates and mixtures in any proportion, also salts and solvates, are new. Bis-aromatic substituted N-ethyl propiolamide derivatives of formula (I) optionally as pure stereoisomers, particularly enantiomers or diastereomers, including racemates and mixtures in any proportion, also salts and solvates, are new. M 1>-CR 1>R 2>-CR 3>R 4>-NR 5>-CO-Ctriple boundC-M 2>(I) M 1>and M 2>optionally substituted aryl or heterocyclic groups; R 1>-R 5>hydrogen or various substituents. The full definitions are given in the DEFINITIONS (Full Definitions) field. An independent claim is included for several methods for preparing (I). ACTIVITY : Analgesic; Antimigraine; Antidepressant; Nootropic; Neuroprotective; Antiparkinsonian; Anticonvulsant; Tranquilizer; Antitussive; Uropathic; Antidiarrheal; Antipruritic; Antiasthma; Cerebroprotective; Ophthalmological; Antialcoholic; Antismoking. MECHANISM OF ACTION : Regulation, particularly inhibition, of the mGluR5 receptor. The compound 3-(3-chlorophenyl)-N-methyl-N-phenethylpropiolamide has IC50 against the porcine mGluR5 receptor of 0.012 mu M.
IPC 8 full level
C07C 233/11 (2006.01); C07C 233/13 (2006.01); C07C 233/22 (2006.01); C07C 235/34 (2006.01); C07C 255/57 (2006.01); C07D 207/32 (2006.01); C07D 209/08 (2006.01); C07D 209/14 (2006.01); C07D 209/16 (2006.01); C07D 213/40 (2006.01); C07D 231/12 (2006.01); C07D 233/54 (2006.01); C07D 333/20 (2006.01); C07D 333/24 (2006.01); C07D 401/12 (2006.01)
CPC (source: EP US)
A61P 1/00 (2017.12 - EP); A61P 1/06 (2017.12 - EP); A61P 1/08 (2017.12 - EP); A61P 1/12 (2017.12 - EP); A61P 1/14 (2017.12 - EP); A61P 3/04 (2017.12 - EP); A61P 7/00 (2017.12 - EP); A61P 7/10 (2017.12 - EP); A61P 9/00 (2017.12 - EP); A61P 9/10 (2017.12 - EP); A61P 11/00 (2017.12 - EP); A61P 11/04 (2017.12 - EP); A61P 11/06 (2017.12 - EP); A61P 11/14 (2017.12 - EP); A61P 13/02 (2017.12 - EP); A61P 13/10 (2017.12 - EP); A61P 15/10 (2017.12 - EP); A61P 15/12 (2017.12 - EP); A61P 17/04 (2017.12 - EP); A61P 21/02 (2017.12 - EP); A61P 23/02 (2017.12 - EP); A61P 25/00 (2017.12 - EP); A61P 25/04 (2017.12 - EP); A61P 25/06 (2017.12 - EP); A61P 25/08 (2017.12 - EP); A61P 25/14 (2017.12 - EP); A61P 25/16 (2017.12 - EP); A61P 25/22 (2017.12 - EP); A61P 25/24 (2017.12 - EP); A61P 25/28 (2017.12 - EP); A61P 25/32 (2017.12 - EP); A61P 25/34 (2017.12 - EP); A61P 25/36 (2017.12 - EP); A61P 27/02 (2017.12 - EP); A61P 29/00 (2017.12 - EP); A61P 43/00 (2017.12 - EP); C07C 233/11 (2013.01 - EP US); C07C 233/13 (2013.01 - EP US); C07C 233/22 (2013.01 - EP US); C07C 235/34 (2013.01 - EP US); C07C 255/57 (2013.01 - EP US); C07D 207/325 (2013.01 - EP US); C07D 209/08 (2013.01 - EP US); C07D 209/14 (2013.01 - EP US); C07D 213/40 (2013.01 - EP US); C07D 231/12 (2013.01 - EP US); C07D 233/54 (2013.01 - EP US); C07D 333/20 (2013.01 - EP US); C07D 333/24 (2013.01 - EP US); C07D 401/12 (2013.01 - EP US); C07D 409/12 (2013.01 - EP US)
Citation (search report)
See references of WO 2007079958A1
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR
DOCDB simple family (publication)
DE 102005062985 A1 20070705; CA 2631360 A1 20070719; EP 1968935 A1 20080917; JP 2009522220 A 20090611; US 2009182020 A1 20090716; WO 2007079958 A1 20070719
DOCDB simple family (application)
DE 102005062985 A 20051228; CA 2631360 A 20061222; EP 06829853 A 20061222; EP 2006012480 W 20061222; JP 2008547889 A 20061222; US 14670008 A 20080626