EP 1968938 A1 20080917 - SUBSTITUTED PROPIOLIC ACID AMIDES AND THEIR USE FOR PRODUCING DRUGS
Title (en)
SUBSTITUTED PROPIOLIC ACID AMIDES AND THEIR USE FOR PRODUCING DRUGS
Title (de)
SUBSTITUIERTE PROPIOLSÄUREAMIDE UND IHRE VERWENDUNG ZUR HERSTELLUNG VON ARZNEIMITTELN
Title (fr)
AMIDES DE L'ACIDE PROPIOLIQUE SUBSTITUES ET LEUR UTILISATION POUR PRODUIRE DES MEDICAMENTS
Publication
Application
Priority
- EP 2006012479 W 20061222
- DE 102005062987 A 20051228
Abstract (en)
[origin: DE102005062987A1] Propiolic acid amides (I), optionally as pure stereoisomers, particularly enantiomers or diastereomers, including racemates and mixtures in any proportion, also salts and solvates, are new. Propiolic acid amides of formula (I), optionally as pure stereoisomers, particularly enantiomers or diastereomers, including racemates and mixtures in any proportion, also salts and solvates, are new. R 1>optionally substituted aryl or heteroaryl; a-f : 0 or 1, totaling 1-6; R 2>-R 13>various substituents; M and W : N or C; P : CR 1>4, N, NR 15>, O or S; Q : CR 16>, N, NR 17>, O or S; T : CR 18>, N, NR 19>, O or S; V : CR 20>, N, NR 21>, O or S; g : 0 or 1; R 14>-R 21>various substituents. The full definitions are given in the DEFINITIONS -Full Definitions field. An independent claim is included for several methods for preparing (I). [Image] ACTIVITY : Analgesic; Antimigraine; Antidepressant; Nootropic; Neuroprotective; Antiparkinsonian; Anticonvulsant; Tranquilizer; Antitussive; Uropathic; Antidiarrheal; Antipruritic; Antiasthma; Cerebroprotective; Ophthalmological; Antialcoholic; Antismoking. MECHANISM OF ACTION : Regulation, particularly inhibition, of the mGluR5 receptor. The compound 1-(3-phenylpropiolyl)-2,3-dihydroindole has IC50 against the porcine mGluR5 receptor of 7.94mu M.
IPC 8 full level
C07D 209/08 (2006.01); A61K 31/44 (2006.01); A61K 31/47 (2006.01); A61K 31/495 (2006.01); A61P 23/00 (2006.01); A61P 25/00 (2006.01); C07D 209/44 (2006.01); C07D 215/08 (2006.01); C07D 217/06 (2006.01); C07D 223/16 (2006.01); C07D 401/06 (2006.01); C07D 471/04 (2006.01); C07D 487/04 (2006.01); C07D 498/04 (2006.01)
CPC (source: EP US)
A61P 1/00 (2017.12 - EP); A61P 1/04 (2017.12 - EP); A61P 1/08 (2017.12 - EP); A61P 1/12 (2017.12 - EP); A61P 3/00 (2017.12 - EP); A61P 3/04 (2017.12 - EP); A61P 9/10 (2017.12 - EP); A61P 11/00 (2017.12 - EP); A61P 11/06 (2017.12 - EP); A61P 13/02 (2017.12 - EP); A61P 17/04 (2017.12 - EP); A61P 21/00 (2017.12 - EP); A61P 23/00 (2017.12 - EP); A61P 25/00 (2017.12 - EP); A61P 25/06 (2017.12 - EP); A61P 25/08 (2017.12 - EP); A61P 25/14 (2017.12 - EP); A61P 25/16 (2017.12 - EP); A61P 25/22 (2017.12 - EP); A61P 25/28 (2017.12 - EP); A61P 25/30 (2017.12 - EP); A61P 25/32 (2017.12 - EP); A61P 25/34 (2017.12 - EP); A61P 25/36 (2017.12 - EP); A61P 27/02 (2017.12 - EP); A61P 29/00 (2017.12 - EP); A61P 35/00 (2017.12 - EP); A61P 43/00 (2017.12 - EP); C07D 209/08 (2013.01 - EP US); C07D 209/44 (2013.01 - EP US); C07D 215/08 (2013.01 - EP US); C07D 217/06 (2013.01 - EP US); C07D 223/16 (2013.01 - EP US); C07D 401/06 (2013.01 - EP US); C07D 471/04 (2013.01 - EP US); C07D 487/04 (2013.01 - EP US)
Citation (search report)
See references of WO 2007079957A1
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR
DOCDB simple family (publication)
DE 102005062987 A1 20070705; CA 2633722 A1 20070719; EP 1968938 A1 20080917; JP 2009522219 A 20090611; US 2009075978 A1 20090319; WO 2007079957 A1 20070719
DOCDB simple family (application)
DE 102005062987 A 20051228; CA 2633722 A 20061222; EP 06829852 A 20061222; EP 2006012479 W 20061222; JP 2008547888 A 20061222; US 14681408 A 20080626