EP 1972927 A1 20080924 - Microelectronic sensor device for detecting label particles
Title (en)
Microelectronic sensor device for detecting label particles
Title (de)
Mikroelektronische Sensorvorrichtung zum Erkennen von Markierungspartikeln
Title (fr)
Dispositif capteur microélectronique pour la détection de particules de marquage
Publication
Application
Priority
EP 07104098 A 20070314
Abstract (en)
The invention relates to a microelectronic sensor device for the detection of target components that comprise label particles, for example magnetic particles (1). The sensor device comprises a carrier (11) with a binding surface (12) at which target components can collect and optionally bind to specific capture elements. An incident light beam (L1) is transmitted into the carrier and totally internally reflected at the binding surface (12). The amount of light in the reflected light beam (L2) and optionally also of fluorescence light emitted by target components at the binding surface is then detected by a light detector (31). Evanescent light generated during the total internal reflection is affected (absorbed, scattered) by target components and/or label particles (1) at the binding surface (12) and will therefore be missing in the reflected light beam (L2). This can be used to determine the amount of target components at the binding surface (12) from the amount of light in the reflected light beam (L2, L2a, L2b). A magnetic field generator (41) is optionally used to generate a magnetic field (B) at the binding surface (12) by which magnetic label particles (1) can be manipulated, for example attracted or repelled.
IPC 8 full level
G01N 21/64 (2006.01)
CPC (source: EP)
G01N 21/552 (2013.01); G01N 21/6428 (2013.01); G01N 21/6452 (2013.01); G01N 21/648 (2013.01)
Citation (search report)
- [X] EP 1650547 A2 20060426 - FUJI PHOTO FILM CO LTD [JP]
- [XY] EP 1079226 A1 20010228 - LEUZE ELECTRONIC GMBH & CO [DE], et al
- [Y] WO 2007010469 A1 20070125 - KONINKL PHILIPS ELECTRONICS NV [NL], et al
- [X] BLICKLE V, ET AL: "Evanescent light scattering wtih magnetic colloids", APPLIED PHYSICS LETTERS, vol. 87, no. 101102, 2005, pages 1 - 3, XP002453212
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR
Designated extension state (EPC)
AL BA HR MK RS
DOCDB simple family (publication)
DOCDB simple family (application)
EP 07104098 A 20070314