EP 1973568 A1 20081001 - CYTOTOXIC ANTIBODIES TARGETING ANTIBODIES INHIBITING FACTOR VIII
Title (en)
CYTOTOXIC ANTIBODIES TARGETING ANTIBODIES INHIBITING FACTOR VIII
Title (de)
ZYTOTOXISCHE ANTIKÖRPER GEGEN HEMMENDE ANTIKÖRPER GEGEN FAKTOR VIII
Title (fr)
ANTICORPS CYTOTOXIQUES DIRIGES CONTRE DES ANTICORPS INHIBITEURS DE FACTEUR VIII
Publication
Application
Priority
- FR 2006002452 W 20061102
- FR 0511146 A 20051102
Abstract (en)
[origin: FR2892724A1] A monoclonal anti-idiotypic antibody (I) for targeting an antibody inhibiting the human factor VIII, is new, where (I) targets the C2 region of the human factor-VIII in which the variable region of each of the light chains is encoded by a sequence of nucleic acids identical to the murine sequence of nucleic acids (SEQ ID No: 1), the variable region of each of the heavy chains is encoded by a sequence of nucleic acids identical to the murine sequence of nucleic acids (SEQ ID No: 2) and the constant regions of the light and heavy chains are constant regions of a murine species. Monoclonal anti-idiotypical antibody (I) to target an antibody inhibiting the human factor VIII, is new, where (I) target the C2 region of the human factor VIII in which the variable region of each of the light chains is encoded by a sequence of nucleic acids of which at least 70% is identical to the murine sequence of nucleic acids having a fully defined 321 amino acid (SEQ ID No: 1) sequence given in the specification, and the variable region of each of the heavy chains is encoded by a sequence of nucleic acids of which at least 70 % is identical to the murine sequence of nucleic acids having a fully defined 366 amino acid (SEQ ID No: 2) sequence given in the specification, the constant regions of the light and heavy chains are constant regions of a murine species. Independent claims are included for: (1) a stable cellular line expressing (I); (2) a R565 clone registered under the registration number 1-3510 in the National Collection of Cultures and of Micro-organisms; (3) a DNA fragment of a sequence having a fully defined 1356 amino acid (SEQ ID No: 6) sequence for the heavy chain; and (4) a DNA fragment of sequence having a fully defined 642 amino acid (SEQ ID No: 5) sequence for the light chain. ACTIVITY : Antianemic. MECHANISM OF ACTION : Human anti-factor-VIII inhibitor; B-cell antigen receptor binder.
IPC 8 full level
A61K 39/395 (2006.01); A61P 7/04 (2006.01)
CPC (source: EP KR US)
A61K 39/395 (2013.01 - KR); A61P 7/04 (2017.12 - EP); C07K 16/00 (2013.01 - KR); C07K 16/42 (2013.01 - KR); C07K 16/4208 (2013.01 - EP US); A61K 2039/505 (2013.01 - EP US); C07K 2317/24 (2013.01 - EP US); C07K 2317/56 (2013.01 - EP US); C07K 2317/565 (2013.01 - EP US)
Citation (search report)
See references of WO 2007051926A1
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR
DOCDB simple family (publication)
FR 2892724 A1 20070504; FR 2892724 B1 20080104; AU 2006310396 A1 20070510; BR PI0619709 A2 20111011; CA 2638166 A1 20070510; CN 101351226 A 20090121; EP 1973568 A1 20081001; EP 2389954 A1 20111130; IL 191150 A0 20081229; JP 2009514516 A 20090409; KR 20080099231 A 20081112; US 2009130094 A1 20090521; US 2011274684 A1 20111110; US 8038993 B2 20111018; WO 2007051926 A1 20070510
DOCDB simple family (application)
FR 0511146 A 20051102; AU 2006310396 A 20061102; BR PI0619709 A 20061102; CA 2638166 A 20061102; CN 200680049924 A 20061102; EP 06831055 A 20061102; EP 11167006 A 20061102; FR 2006002452 W 20061102; IL 19115008 A 20080429; JP 2008538382 A 20061102; KR 20087013149 A 20080530; US 201113104939 A 20110510; US 8445906 A 20061102