Global Patent Index - EP 1973952 A4

EP 1973952 A4 20100901 - CONJUGATE COMPRISING PHARMACEUTICAL ACTIVE COMPOUND COVALENTLY BOUND TO MUCOADHESIVE POLYMER AND TRANSMUCOSAL DELIVERY METHOD OF PHARMACEUTICAL ACTIVE COMPOUND USING THE SAME

Title (en)

CONJUGATE COMPRISING PHARMACEUTICAL ACTIVE COMPOUND COVALENTLY BOUND TO MUCOADHESIVE POLYMER AND TRANSMUCOSAL DELIVERY METHOD OF PHARMACEUTICAL ACTIVE COMPOUND USING THE SAME

Title (de)

KONJUGAT, UMFASSEND EINE KOVALENT AN EIN MUCOADHÄSIVES POLYMER GEBUNDENE PHARMAZEUTISCH WIRKSAME VERBINDUNG, UND TRANSMUCOSALE VERABREICHUNGSMETHODE FÜR EINE PHARMAZEUTISCH WIRKSAME VERBINDUNG UNTER ANWENDUNG DAVON

Title (fr)

CONJUGUÉ COMPRENANT UN COMPOSÉ PHARMACEUTIQUEMENT ACTIF LIÉ DE FAÇON COVALENTE À UN POLYMÈRE MUCOADHÉSIF ET MÉTHODE D'ADMINISTRATION TRANSMUCOSALE DE COMPOSÉ PHARMACEUTIQUEMENT ACTIF FAISANT APPEL AUDIT CONJUGUÉ

Publication

EP 1973952 A4 20100901 (EN)

Application

EP 07701046 A 20070123

Priority

  • KR 2007000403 W 20070123
  • KR 20060006632 A 20060123
  • KR 20060068801 A 20060722
  • KR 20060068804 A 20060722

Abstract (en)

[origin: WO2007083984A1] Provided is a conjugate comprising a pharmacologically active substance covalently bound to a mucoadhesive polymer and a method for transmucosal delivery of a pharmacologically active substance using the same. Specifically, the present invention is directed to a conjugate comprising a pharmacologically active substance covalently bound via a linker to a mucoadhesive polymer; a pharmaceutical composition for transmucosal administration of a drug, comprising the aforementioned conjugate and a pharmaceutically acceptable carrier; and a method for in vivo delivery of a pharmacologically active substance via a transmucosal route, by covalent binding of the active substance with a mucoadhesive polymer via a linker. The conjugate of the present invention exhibits excellent absorption rate and biocompatibility in biological mucous membranes, particularly mucous membranes of the alimentary canal (especially the gastrointestinal tract), in vivo degradability, and superior bioavailability even with oral administration, thus enabling treatment of diseases via oral administration of a drug.

IPC 8 full level

C07K 17/08 (2006.01); A61K 47/48 (2006.01); C07K 17/10 (2006.01)

CPC (source: EP US)

A61K 9/0034 (2013.01 - US); A61K 9/0043 (2013.01 - US); A61K 9/0048 (2013.01 - US); A61K 9/0053 (2013.01 - US); A61K 9/006 (2013.01 - US); A61K 47/61 (2017.07 - EP US); A61P 3/10 (2017.12 - EP); A61P 35/00 (2017.12 - EP); C07K 14/62 (2013.01 - EP US)

Citation (search report)

  • [XY] WO 0112230 A1 20010222 - PARK MYUNG OK [KR], et al
  • [X] WO 0105434 A2 20010125 - AMGEN INC [US], et al
  • [X] US 2005186174 A1 20050825 - BOSSARD MARY J [US]
  • [X] EP 1080732 A1 20010307 - DAIICHI SEIYAKU CO [JP]
  • [XP] EP 1710257 A1 20061011 - SEIKAGAKU KOGYO CO LTD [JP]
  • [X] EP 0725141 A1 19960807 - TOVARISCHESTVO S ORGANICHENNOI [RU]
  • [XP] WO 2006042146 A2 20060420 - UNIV EMORY [US], et al
  • [X] KRUM KAFEDJIISKI ET AL: "Synthesis and in Vitro Evaluation of a Novel Chitosan-Glutathione Conjugate", PHARMACEUTICAL RESEARCH, KLUWER ACADEMIC PUBLISHERS-PLENUM PUBLISHERS, NE LNKD- DOI:10.1007/S11095-005-6248-6, vol. 22, no. 9, 1 September 2005 (2005-09-01), pages 1480 - 1488, XP019370937, ISSN: 1573-904X
  • [X] YOUHUA SONG ET AL: "SYNTHESIS AND DRUG-RELEASE CHARACTERISTICS OF THE CONJUGATES OF MITOMYCIN C WITH N-SUCCINYL-CHITOSAN AND CARBOXYMETHYL-CHITIN", CHEMICAL AND PHARMACEUTICAL BULLETIN, PHARMACEUTICAL SOCIETY OF JAPAN, TOKYO, JP, vol. 40, no. 10, 1 October 1992 (1992-10-01), pages 2822 - 2825, XP000324876, ISSN: 0009-2363
  • [X] ORIENTI I ET AL: "Chitosan-indomethacin conjugates. Effect of different substituents on the polysaccharide molecule on drug release", ARCHIV DER PHARMAZIE, VCH VERLAGSGESELLSCHAFT MBH, WEINHEIM, DE LNKD- DOI:10.1002/ARDP.19963290505, vol. 329, no. 5, 1 January 1996 (1996-01-01), pages 245 - 250, XP008081220, ISSN: 0365-6233
  • [Y] ILLUM L ET AL: "CHITOSAN AS A NOVEL NASAL DELIVERY SYSTEM FOR PEPTIDE DRUGS", PHARMACEUTICAL RESEARCH, KLUWER ACADEMIC PUBLISHERS, NEW YORK, NY, US LNKD- DOI:10.1023/A:1018901302450, vol. 11, no. 8, 1 August 1994 (1994-08-01), pages 1186 - 1189, XP000570481, ISSN: 0724-8741
  • [Y] WEST KEVIN R ET AL: "Reversible covalent chemistry in drug delivery.", CURRENT DRUG DISCOVERY TECHNOLOGIES, vol. 2, September 2005 (2005-09-01), pages 123 - 160, XP008124424
  • [A] SALAMAT-MILLER N ET AL: "The use of mucoadhesive polymers in buccal drug delivery", ADVANCED DRUG DELIVERY REVIEWS, ELSEVIER BV, AMSTERDAM, NL LNKD- DOI:10.1016/J.ADDR.2005.07.003, vol. 57, no. 11, 3 November 2005 (2005-11-03), pages 1666 - 1691, XP025284004, ISSN: 0169-409X, [retrieved on 20051103]
  • See references of WO 2007083984A1

Citation (examination)

  • WO 9609805 A2 19960404 - ZONAGEN INC [US]
  • TARKOWSKI ANDREJ ET AL: "Treatment of experimental autoimmune arthritis by nasal administration of a type II collagen-cholera toxoid conjugate vaccine", ARTHRITIS AND RHEUMATISM, vol. 42, no. 8, August 1999 (1999-08-01), pages 1628 - 1634, XP055057886, ISSN: 0004-3591

Designated contracting state (EPC)

AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR

DOCDB simple family (publication)

WO 2007083984 A1 20070726; EP 1973952 A1 20081001; EP 1973952 A4 20100901; JP 2009508852 A 20090305; JP 2012051946 A 20120315; JP 5491485 B2 20140514; US 2007292387 A1 20071220; US 2014256623 A1 20140911; US 2017252453 A9 20170907

DOCDB simple family (application)

KR 2007000403 W 20070123; EP 07701046 A 20070123; JP 2008531031 A 20070123; JP 2011268031 A 20111207; US 201414286969 A 20140523; US 84723707 A 20070829