EP 1978988 A2 20081015 - PEPTIDE-BASED REGULATION OF GAP JUNCTIONS
Title (en)
PEPTIDE-BASED REGULATION OF GAP JUNCTIONS
Title (de)
PEPTIDBASIERTE REGULIERUNG VON GAP-JUNCTIONS
Title (fr)
REGULATION DE JONCTIONS COMMUNICANTES A L AIDE DE PEPTIDES
Publication
Application
Priority
- US 2007060584 W 20070116
- US 75888606 P 20060113
Abstract (en)
[origin: WO2007084895A2] The present invention relates to proteins and polypeptides that (i) have the formula A-[W-A]<SUB>n</SUB> where A is a peptide of formula XXXXRXPXXXX where X is any amino acid, R is arginine, and P is proline; W is a linker; and n is any number from 1 through 5; or (ii) consist essentially of the formula X<SUB>n</SUB>RXPX<SUB>3n</SUB> where each X is any amino acid, R is arginine, P is proline, n is any number from zero to fifteen, m is any number from zero to fifteen, and the sum of n and m is between ten and fifteen. Methods using these proteins and polypeptides to: screen for compounds that modulate Cx43CT, measure Cx43CT-binding affinity of a compound that binds to Cx43CT, and identify the location of an RXP-binding domain of Cx43CT, are also disclosed.
IPC 8 full level
A61K 38/10 (2006.01); C07K 7/08 (2006.01)
CPC (source: EP)
C07K 7/08 (2013.01); C07K 14/001 (2013.01); A61K 38/00 (2013.01)
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR
Designated extension state (EPC)
AL BA HR MK RS
DOCDB simple family (publication)
WO 2007084895 A2 20070726; WO 2007084895 A3 20080814; EP 1978988 A2 20081015; EP 1978988 A4 20091104
DOCDB simple family (application)
US 2007060584 W 20070116; EP 07718080 A 20070116