EP 1981861 A2 20081022 - NOVEL METHOD FOR SYNTHESIS OF 1,4-MORPHOLINE-2,5-DIONES
Title (en)
NOVEL METHOD FOR SYNTHESIS OF 1,4-MORPHOLINE-2,5-DIONES
Title (de)
NEUES VERFAHREN ZUR SYNTHESE VON 1,4-MORPHOLIN-2,5-DIONEN
Title (fr)
NOUVELLE METHODE DE SYNTHESE DE L,4-MORPHOLINE-2,5-DIONES
Publication
Application
Priority
- FR 2007000135 W 20070124
- FR 0600662 A 20060125
Abstract (en)
[origin: FR2896502A1] Preparation of 1,4-morpholine-2,5-diones (I) comprises oxidation of the ketone group of a cyclic compound (II). Preparation of 1,4-morpholine-2,5-diones of formula (I) comprises oxidation of the ketone group of a cyclic compound of formula (II). R, R 1-R 4H, halo, 2-6C alkenyl, 3-7C cycloalkyl, cyclohexenyl or -(CH 2) m-V 1-W 1; V 1a covalent bond, S or O, -C(O)-O- or -NR a-; R a, W 1H, 1-8C alkyl (optionally substituted by halo or cyano) or aryl (preferably phenyl) or aralkyl (preferably benzyl) (optionally substituted by -(CH 2) n-Y 1-Z, halo, nitro or CN); Y 1O,-S or a covalent bond; Z : H, 1-6C alkyl (optionally substituted by halo) or aralkyl (preferably benzyl); and m, n : 0-4. An independent claim is included for (I) susceptible to be obtained by the process. Provided that (I) is other than the compounds in which: R 1is methyl, R 2and R 3are hydrogen and R4 the atom hydrogen, methyl, benzyloxymethyl, benzyloxycarboxymethyl, p-(methoxy)benzylthiomethyl or p-(benzyloxy) benzyl; R 1is isopropyl, R 2, R 3and R 4are hydrogen; or R 1is p-(methoxy)benzyl, R 2and R 3are hydrogen and R 4is isopropyl. [Image].
IPC 8 full level
C07D 265/32 (2006.01)
CPC (source: EP US)
C07D 265/32 (2013.01 - EP US)
Citation (search report)
See references of WO 2007085729A2
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR
Designated extension state (EPC)
AL BA HR MK RS
DOCDB simple family (publication)
FR 2896502 A1 20070727; FR 2896502 B1 20100924; CA 2640031 A1 20070802; CN 101374822 A 20090225; EP 1981861 A2 20081022; JP 2009528982 A 20090813; RU 2008134461 A 20100227; US 2010036120 A1 20100211; WO 2007085729 A2 20070802; WO 2007085729 A3 20080424
DOCDB simple family (application)
FR 0600662 A 20060125; CA 2640031 A 20070124; CN 200780003517 A 20070124; EP 07730853 A 20070124; FR 2007000135 W 20070124; JP 2008551822 A 20070124; RU 2008134461 A 20070124; US 16233407 A 20070124