EP 1986619 A4 20100428 - USE OF PHOSPHATASES TO TREAT TUMORS OVEREXPRESSING N-COR
Title (en)
USE OF PHOSPHATASES TO TREAT TUMORS OVEREXPRESSING N-COR
Title (de)
VERWENDUNG VON PHOSPHATASEN ZUR BEHANDLUNG VON TUMOREN DURCH N-COR-ÜBEREXPRESSION
Title (fr)
UTILISATION DE PHOSPHATASE POUR TRAITER DES TUMEURS SUREXPRIMANT N-COR
Publication
Application
Priority
- US 2007003095 W 20070206
- US 77116306 P 20060206
- US 79720106 P 20060502
Abstract (en)
[origin: WO2007092414A2] This invention provides a method of treating a patient suffering from a tumor overexpressing N-CoR comprising administering to the patient a phosphatase ligand, alone or in combination with "a retinoid receptor ligand, a histone deacetylase ligand, or both, in amounts effective to treat the patient. This invention also provides a method of inhibiting tumor growth in a patient suffering from a tumor overexpressing N-CoR. This invention further provides a method of identifying a compound or a mixture of compounds capable of inducing differentiation of cells of a tumor overexpressing N- CoR. This invention still further provides a method of determining the likelihood of successfully treating a subject suffering from a tumor overexpressing N-CoR. This invention also provides a method of assessing the- likelihood that a patient is suffering from a tumor overexpressing N-CoR. This invention yet also provides a method of assessing the likelihood that a patient previously suffering from and treated for a tumor overexpressing N-CoR has suffered a recurrence of a tumor overexpressing N-CoR. Finally, this invention provides analogous methods for use on glioblastoma multiforme.
IPC 8 full level
A61K 31/00 (2006.01); A61P 35/00 (2006.01)
CPC (source: EP)
A61K 31/519 (2013.01); A61P 35/00 (2017.12)
Citation (search report)
- [X] FR 2872704 A1 20060113 - SCHWARTZ LAURENT [FR], et al
- [XI] WO 03092719 A2 20031113 - YISSUM RES DEV CO [IL], et al
- [X] US 2004209934 A1 20041021 - MCCLUSKEY ADAM [AU], et al
- [I] WO 0228387 A1 20020411 - ONCOPHARMACEUTICAL INC [US]
- [I] WO 0209680 A2 20020207 - WALTER MICHAEL [DE]
- [I] US 6262116 B1 20010717 - PANDOLFI PIER PAOLO [US], et al
- [X] KOK S-H ET AL: "Norcantharidin-induced apoptosis in oral cancer cells is associated with an increase of proapoptotic to antiapoptotic protein ratio", CANCER LETTERS, NEW YORK, NY, US, vol. 217, no. 1, 10 January 2005 (2005-01-10), pages 43 - 52, XP004681287, ISSN: 0304-3835
- [IP] HILL ET AL: "Heterocyclic substituted cantharidin and norcantharidin analogues-synthesis, protein phosphatase (1 and 2A) inhibition, and anti-cancer activity", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, ELSEVIER SCIENCE, GB, vol. 17, no. 12, 15 June 2007 (2007-06-15), pages 3392 - 3397, XP022097790, ISSN: 0960-894X
- [I] LEE MI-OCK ET AL: "Role of coactivators and corepressors in the induction of the RARbeta gene in human colon cancer cells.", BIOLOGICAL AND PHARMACEUTICAL BULLETIN, vol. 25, no. 10, October 2002 (2002-10-01), pages 1298 - 1302, XP002572865, ISSN: 0918-6158
- [I] FRASOR JONNA ET AL: "Estrogen down-regulation of the corepressor N-CoR: Mechanism and implications for estrogen derepression of N-CoR-regulated genes", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 102, no. 37, September 2005 (2005-09-01), pages 13153 - 13157, XP002572866, ISSN: 0027-8424
- See references of WO 2007092414A2
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 2007092414 A2 20070816; WO 2007092414 A3 20080515; WO 2007092414 A8 20080904; CA 2641308 A1 20070816; EP 1986619 A2 20081105; EP 1986619 A4 20100428
DOCDB simple family (application)
US 2007003095 W 20070206; CA 2641308 A 20070206; EP 07763614 A 20070206