Global Patent Index - EP 1987148 A4

EP 1987148 A4 20090805 - DE-DIFFERENTIATION OF ASTROCYTES INTO NEURAL STEM CELL USING BMI-1

Title (en)

DE-DIFFERENTIATION OF ASTROCYTES INTO NEURAL STEM CELL USING BMI-1

Title (de)

DEDIFFERENZIERUNG VON ASTROZYTEN ZU NEURALEN STAMMZELLEN UNTER VERWENDUNG VON BMI-1

Title (fr)

DEDIFFÉRENCIATION D'ASTROCYTES EN CELLULES SOUCHES NEURONALES AU MOYEN DU GÈNE BMI-1

Publication

EP 1987148 A4 20090805 (EN)

Application

EP 06732855 A 20060412

Priority

  • KR 2006001350 W 20060412
  • KR 20060019018 A 20060227

Abstract (en)

[origin: WO2007097494A1] Disclosed are a composition and a method for inducing the de-differentiation of astrocytes into neural stem cells using Bmi-1. The de-differentiated neural stem cells have the ability to differentiate into astrocytes, neurons, and oligodendrocytes.

IPC 8 full level

C12N 15/64 (2006.01); A61K 48/00 (2006.01); C12N 5/0797 (2010.01); C12N 15/00 (2006.01); C12N 15/867 (2006.01)

CPC (source: EP KR)

C07K 14/82 (2013.01 - EP); C12N 5/0623 (2013.01 - EP); C12N 15/11 (2013.01 - KR); C12N 15/64 (2013.01 - KR); C12N 2500/25 (2013.01 - EP); C12N 2501/11 (2013.01 - EP); C12N 2501/115 (2013.01 - EP); C12N 2501/392 (2013.01 - EP); C12N 2501/60 (2013.01 - EP); C12N 2506/08 (2013.01 - EP)

Citation (search report)

  • [X] US 2003022375 A1 20030130 - ITOH AKIRA [JP], et al
  • [XD] ZENCAK DUSAN ET AL: "Bmi1 loss produces an increase in astroglial cells and a decrease in neural stem cell population and proliferation.", THE JOURNAL OF NEUROSCIENCE : THE OFFICIAL JOURNAL OF THE SOCIETY FOR NEUROSCIENCE 15 JUN 2005, vol. 25, no. 24, 15 June 2005 (2005-06-15), pages 5774 - 5783, XP002533121, ISSN: 1529-2401
  • [AD] MOLOFSKY A V ET AL: "Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation", NATURE, NATURE PUBLISHING GROUP, LONDON, UK, vol. 425, no. 6961, 30 October 2003 (2003-10-30), pages 962 - 967, XP002324138, ISSN: 0028-0836
  • [A] ALKEMA M J ET AL: "CHARACTERIZATION AND CHROMOSOMAL LOCALIZATION OF THE HUMAN PROTO-ONCOGENE BMI-1", HUMAN MOLECULAR GENETICS, OXFORD UNIVERSITY PRESS, SURREY, vol. 2, no. 10, 1 October 1993 (1993-10-01), pages 1597 - 1603, XP000676533, ISSN: 0964-6906
  • [DA] JOANNIDES ALEXIS ET AL: "Efficient generation of neural precursors from adult human skin: astrocytes promote neurogenesis from skin-derived stem cells.", LANCET 2004 JUL 10-16, vol. 364, no. 9429, 10 July 2004 (2004-07-10), pages 172 - 178, XP002533122, ISSN: 1474-547X
  • [DA] PARK IN-KYUNG ET AL: "Bmi1, stem cells, and senescence regulation.", THE JOURNAL OF CLINICAL INVESTIGATION JAN 2004, vol. 113, no. 2, January 2004 (2004-01-01), pages 175 - 179, XP002533123, ISSN: 0021-9738
  • [T] MOON J H ET AL: "Induction of neural stem cell-like cells (NSCLCs) from mouse astrocytes by Bmi1", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC. ORLANDO, FL, US, vol. 371, no. 2, 27 June 2008 (2008-06-27), pages 267 - 272, XP022659023, ISSN: 0006-291X, [retrieved on 20080424]
  • See references of WO 2007097494A1

Designated contracting state (EPC)

AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR

DOCDB simple family (publication)

WO 2007097494 A1 20070830; CN 101389761 A 20090318; EP 1987148 A1 20081105; EP 1987148 A4 20090805; JP 2009528050 A 20090806; KR 100844971 B1 20080709; KR 20070089089 A 20070830

DOCDB simple family (application)

KR 2006001350 W 20060412; CN 200680053500 A 20060412; EP 06732855 A 20060412; JP 2008557196 A 20060412; KR 20070019600 A 20070227