EP 1991565 B1 20150121 - Shiga toxoid chimeric proteins
Title (en)
Shiga toxoid chimeric proteins
Title (de)
Chimäre Shigatoxoidproteine
Title (fr)
Protéines chimériques du toxoïde de shiga
Publication
Application
Priority
- US 2007004513 W 20070216
- US 77365806 P 20060216
Abstract (en)
[origin: WO2007098201A2] A chimeric Shiga toxoid according to the invention contains an enzymatically- inactivated StxA subunit and a native StxB subunit. This hybrid Shiga toxoid induces the production of broadly cross-reactive species of antibodies against Shiga toxin following immunization. The StxA subunit is modified so that it is enzymatically inactive. The invention thus encompasses the Shiga toxoid or fragments thereof and the nucleic acid sequence of the Shiga toxoid or fragments thereof. The invention further encompasses the production of a Shiga toxoid, the production of antibodies using the Shiga toxoid and methods of productions, and an immunogenic composition containing the Shiga toxoid.
IPC 8 full level
C07K 14/245 (2006.01); A61K 39/02 (2006.01); A61K 39/108 (2006.01); C12N 15/62 (2006.01)
CPC (source: EP US)
A61K 39/0258 (2013.01 - EP US); A61P 1/12 (2018.01 - EP); C07K 14/245 (2013.01 - EP US); C12N 15/62 (2013.01 - EP US); A61K 39/00 (2013.01 - EP US); A61K 2039/55566 (2013.01 - EP US); C07K 2319/55 (2013.01 - EP US); Y02A 50/30 (2018.01 - EP US)
Citation (examination)
- PERERA L P ET AL: "ISOLATION AND CHARACTERIZATION OF MONOCLONAL ANTIBODIES TO SHIGA-LIKE TOXIN II OF ENTEROHEMORRHAGIC ESCHERICHIA COLI AND USE OF THE MONOCLONAL ANTIBODIES IN A COLONY ENZYME-LINKED IMMUNOSORBENT ASSAY", JOURNAL OF CLINICAL MICROBIOLOGY, AMERICAN SOCIETY FOR MICROBIOLOGY, WASHINGTON, DC, US, vol. 26, no. 10, 1 October 1988 (1988-10-01), pages 2127 - 2131, XP002923371, ISSN: 0095-1137
- SMITH M J ET AL: "Monoclonal antibody 11E10, which neutralizes Shiga toxin type 2 (Stx2), recognizes three regions on the Stx2 A subunit, blocks the enzymatic action of the toxin in vitro, and alters the overall cellular distribution of the toxin", INFECTION AND IMMUNITY, AMERICAN SOCIETY FOR MICROBIOLOGY, WASHINGTON, US, vol. 77, no. 7, 1 July 2009 (2009-07-01), pages 2730 - 2740, XP009129269, ISSN: 0019-9567, [retrieved on 20090511], DOI: 10.1128/IAI.00005-09
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 2007098201 A2 20070830; WO 2007098201 A3 20090416; AU 2007217782 A1 20070830; CA 2642451 A1 20070830; CA 2642451 C 20161220; EP 1991565 A2 20081119; EP 1991565 A4 20091209; EP 1991565 B1 20150121; ES 2532985 T3 20150406; JP 2009527226 A 20090730; JP 5409014 B2 20140205; US 2009226469 A1 20090910; US 8846058 B2 20140930
DOCDB simple family (application)
US 2007004513 W 20070216; AU 2007217782 A 20070216; CA 2642451 A 20070216; EP 07751283 A 20070216; ES 07751283 T 20070216; JP 2008555421 A 20070216; US 27942307 A 20070216