EP 1993550 A4 20100421 - GSK-3 INHIBITORS FOR THE TREATMENT OF OSTEOPOROSIS

Title (en)

GSK-3 INHIBITORS FOR THE TREATMENT OF OSTEOPOROSIS

Title (de)

GSK-3-HEMMER ZUR BEHANDLUNG VON OSTEOPOROSE

Title (fr)

INHIBITEURS DE GSK-3 DESTINÉS AU TRAITEMENT DE L'OSTÉOPOROSE

Publication

EP 1993550 A4 20100421 (EN)

Application

EP 07716035 A 20070306

Priority

SE 2007000216 W 20070306
US 78025206 P 20060308

Abstract (en)

[origin: US2007213322A1] The present invention relates to a new use of a compound of the formula (I) wherein R1 is NH2, piperazin-1-yl, 4-methylpiperazin-1-yl, 4-methyl-1,4-diazepan-1-yl or 4-ethylpiperazin-1-yl; R2 is hydrogen, fluoro, CH3, CH2CH3, OCH3, CF3 or OCF3; R3 is hydrogen, CH3 or fluoro; as a free base or a pharmaceutically acceptable salt thereof, in the manufacture of a medicament for the prevention and/or treatment of bone-related disorders, osteoporosis and increasing bone formation, bone mineral density. The present invention further relates to a method of prevention and/or treatment of these disorders.

IPC 8 full level

A61K 31/497 (2006.01); A61P 19/10 (2006.01)

CPC (source: EP KR US)

A61K 31/497 (2013.01 - EP KR US); A61K 31/551 (2013.01 - EP US); A61P 19/00 (2017.12 - EP); A61P 19/08 (2017.12 - EP); A61P 19/10 (2017.12 - EP); A61P 43/00 (2017.12 - EP); C07D 241/14 (2013.01 - KR); C07D 403/08 (2013.01 - KR)

Citation (search report)

[Y] WO 2004055006 A1 20040701 - ASTRAZENECA AB [SE], et al
[Y] WO 03004475 A1 20030116 - ASTRAZENECA AB [SE], et al
[Y] WO 03057202 A1 20030717 - HOFFMANN LA ROCHE [CH]
[YP] KULKARNI NALINI H ET AL: "Orally bioavailable GSK-3alpha/beta dual inhibitor increases markers of cellular differentiation in vitro and bone mass in vivo", JOURNAL OF BONE AND MINERAL RESEARCH, AMERICAN SOCIETY FOR BONE AND MINERAL RESEARCH, NEW YORK, NY, US, vol. 21, no. 6, 1 June 2006 (2006-06-01), pages 910 - 920, XP007910933, ISSN: 0884-0431
[A] SMITH E ET AL: "Glucocorticoids inhibit the transcriptional activity of LEF/TCF in differentiating osteoblasts in a glycogen synthase kinase-3[beta]-dependent and -independent manner", JOURNAL OF BIOLOGICAL CHEMISTRY 20050121 US, vol. 280, no. 3, 21 January 2005 (2005-01-21), pages 2388 - 2394, XP007910962, ISSN: 0021-9258
[A] G-AMLAK MAAZA ET AL: "Regulation of myeloma cell growth through Akt/Gsk3/forkhead signaling pathway.", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 4 OCT 2002, vol. 297, no. 4, 4 October 2002 (2002-10-04), pages 760 - 764, XP007910959, ISSN: 0006-291X
See references of WO 2007102770A1

Designated contracting state (EPC)

AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR

Designated extension state (EPC)

DOCDB simple family (publication)

US 2007213322 A1 20070913; US 7576093 B2 20090818; AR 059754 A1 20080430; AU 2007222199 A1 20070913; BR PI0708619 A2 20110607; CA 2644751 A1 20070913; CN 101394851 A 20090325; EP 1993550 A1 20081126; EP 1993550 A4 20100421; IL 193484 A0 20090803; JP 2009529041 A 20090813; KR 20080114717 A 20081231; MX 2008011417 A 20080922; NO 20084182 L 20081205; TW 200800203 A 20080101; UY 30192 A1 20071031; WO 2007102770 A1 20070913; WO 2007102770 A8 20080131; ZA 200807234 B 20090930

DOCDB simple family (application)

US 68345807 A 20070308; AR P070100917 A 20070306; AU 2007222199 A 20070306; BR PI0708619 A 20070306; CA 2644751 A 20070306; CN 200780007963 A 20070306; EP 07716035 A 20070306; IL 19348408 A 20080814; JP 2008558230 A 20070306; KR 20087021787 A 20080905; MX 2008011417 A 20070306; NO 20084182 A 20081006; SE 2007000216 W 20070306; TW 96107083 A 20070302; UY 30192 A 20070307; ZA 200807234 A 20080821