EP 1994013 A4 20090401 - PROCESS FOR PRODUCING PURE AND STABLE FORM OF 2-METHYL-4-(4- METHYL- 1 -PIPERAZINYL)-10H-THIENO[2,3-b] [1,5]BENZODIAZEPINE
Title (en)
PROCESS FOR PRODUCING PURE AND STABLE FORM OF 2-METHYL-4-(4- METHYL- 1 -PIPERAZINYL)-10H-THIENO[2,3-b] [1,5]BENZODIAZEPINE
Title (de)
VERFAHREN ZUR HERSTELLUNG EINER REINEN UND STABILEN FORM VON 2-METHYL-4-(4-METHYL-1-PIPERAZINYL)-10H-THIENO[2,3-B][1,5]BENZODIAZEPIN
Title (fr)
PROCÉDÉ DE PRODUCTION D'UNE FORME PURE ET STABLE DE 2-MÉTHYL-4-(4- MÉTHYL-1-PIPÉRAZINYL)-10H-THIÉNO[2,3-b] [1,5]BENZODIAZÉPINE
Publication
Application
Priority
IN 2006000091 W 20060314
Abstract (en)
[origin: WO2007105225A1] Disclosed is an improved process for producing pure and thermally color stable crystalline Form I of 2-methyl-4-(4-methyl-l-piperazinyl)-10H-thieno[2,3-b][l,5] benzodiazepine and product thereof. The process comprises of reacting 2-(2- aminoanilino)-5-methylthiophene-3-carbonitrile with N-methyl piperazine in conjunction with N-methylpiperazine acid salt, to produce 2-methyl-4-(4-methyl-l- piperazinyl)-10H-thieno[2,3-b][l,5] benzodiazepine. Also disclosed is a process for obtaining the Polymorphic Form I of 2-methyl-4-(4-methyl-l-piperazinyl)-10H- thieno[2,3-b][l ,5J benzodiazepine by crystallizing the crude 2-methyl-4-(4-methyl-l- piperazinyl)-10H-thieno [2,3-b][l ,5] benzodiazepine in a mixture of solvents. Further the invention also provides a new polymorph of Olanzapine, dihydrate Form Ji and process for its preparation and a new hydrate Form J<SUB>2</SUB> of Olanzapine having moisture content 1 -3% and process for its preparation.
IPC 8 full level
C07D 495/04 (2006.01)
CPC (source: EP)
A61P 1/08 (2017.12); A61P 25/18 (2017.12); A61P 25/22 (2017.12); C07D 495/04 (2013.01)
Citation (search report)
- [X] WO 2006006180 A1 20060119 - JUBILANT ORGANOSYS LTD [IN], et al
- See references of WO 2007105225A1
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 2007105225 A1 20070920; EP 1994013 A1 20081126; EP 1994013 A4 20090401; JP 2009530267 A 20090827
DOCDB simple family (application)
IN 2006000091 W 20060314; EP 06728410 A 20060314; JP 2009500003 A 20060314