EP 1994037 A1 20081126 - ORGANOMAGNESIUM SYNTHESIS AGENT
Title (en)
ORGANOMAGNESIUM SYNTHESIS AGENT
Title (de)
MAGNESIUMORGANISCHES SYNTHESEMITTEL
Title (fr)
AGENT DE SYNTHESE MAGNESIUM ORGANIQUE
Publication
Application
Priority
- EP 2007052049 W 20070305
- DE 102006010410 A 20060303
Abstract (en)
[origin: DE102007010953A1] Magnesium organic synthesis agent (A) comprises a solvent with at least an oxygen donor compound (I); and at least a magnesium organic compound (II) excluding benzyl compound (III) and propen-3-yl compound (IV). Magnesium organic synthesis agent (A) comprises a solvent with at least an oxygen donor compound of formula (I); and at least a magnesium organic compound (II) of formula (R-MgX) or (R-Mg-R) excluding benzyl-MgX compound of formula (III) and propen-3-yl-MgX compound (IV) of formula (R 3>2C=C(R 3>)-CR 3>2-MgX). R 1>, R 2>H, optionally functionalized 1-20C-(cyclo)alkyl- or -(cyclo)alkyloxy, 1-12C-(het)aryl or -aryloxy; R : optionally functionalized 1-20C-(halo)alkyl, -alkoxy-, 2-20C-haloalkoxy, 2-20C-alkenyl, 2-20C-alkynyl, 3-8C-cycloalkyl and/or optionally functionalized 3-12C- phenyl, -phenoxy, -(het)aryl, where the halo is F or Cl; X : F, Cl, Br, I, triflate and/or tosylate; and R 3>H, F, Cl, 1-8C-(halo)alkyl, 1-8C(halo)-alkoxy, 2-6C-alkenyl, 5-6C-cyclolkyl, trimethylsilyl, phenyl and/or phenoxy. Provided that: when R 1>is H, then R 2>is not H. An independent claim is included for a method for the preparation of (A) comprising preparing and dispersing magnesium in a solvent, activating the magnesium and adding a compound (V) of formula (R-X). [Image].
IPC 8 full level
C07F 3/02 (2006.01); C07B 49/00 (2006.01)
CPC (source: EP US)
C07B 37/04 (2013.01 - EP US); C07B 49/00 (2013.01 - EP US); C07F 3/02 (2013.01 - EP US)
Citation (search report)
See references of WO 2007099173A1
Citation (examination)
- US 2872471 A 19590203 - RAMSDEN HUGH E, et al
- US 3584027 A 19710608 - DAMLE SURESH B, et al
- "Kirk Othmer Encyclopaedia of Chemical Technology", 1998, pages: 176 - 177
- "Kirk Othmer Encyclopaedia of Chemical Technology", 2005, pages: 279 - 285
- POPPE, L. ET AL.: "Convenient synthesis of monoprotected 1,2-diols", SYNTHETIC COMMUNICATIONS, vol. 25, 1995, pages 3993 - 4000
- "Great Lakes Chemical data sheet for 2-methyltetrahydrofuran", 1995
- "Penn Specialty Chemicals Inc. Data sheet for methylterahydrofuran", 2005
- WOTIZ, J.H. ET AL.: "Reaction of 1-alkynes with organometallic compounds", JOURNAL OF ORGANIC CHEMISTRY, vol. 30, 1965, pages 1240 - 1241
Citation (third parties)
Third party :
- ARZA SEIDEL: "Kirk-Othmer Encyclopedia of Chemical Technology 5th edition", vol. 12, 2005, JOHN WILEY & SONS, ISBN: 0-471-48494-6, article "Furan Derivatives", pages: 279 - 280,285, XP003028316
- POPPE L. ET AL: "Convenient Synthesis of monoprotected 1,2-Diols", SYNTHETIC COMMUNICATIONS, vol. 25, no. 24, 1995, pages 3993 - 4000, XP003028317
- "QO 2-Methyltetrahydrofuran", GREAT LAKES CHEMICAL CORPORATION, November 1995 (1995-11-01), pages 1 - 2, XP003028318
- "Methyltetrahydrofuran", THE FURAN CHEMISTRY SPECIALISTS, 2005, pages 1 - 8, XP003028319
- JOHN H. WOTIZ ET AL: "The Reaction of l-Alkynes with organometallic compounds. XII the rate of reaction Ethyl Grignards with l-llexyne in certain Ethers", MARSHALL UNIVERSITY, 16 June 1964 (1964-06-16), pages 1240 - 1241, XP003028320
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR
DOCDB simple family (publication)
DE 102007010953 A1 20070906; CN 101443337 A 20090527; EP 1994037 A1 20081126; US 2009173914 A1 20090709; US 9534001 B2 20170103; WO 2007099173 A1 20070907
DOCDB simple family (application)
DE 102007010953 A 20070305; CN 200780007635 A 20070305; EP 07712440 A 20070305; EP 2007052049 W 20070305; US 27972407 A 20070305