Global Patent Index - EP 1996619 A4

EP 1996619 A4 20091118 - GPCRS AS ANGIOGENESIS TARGETS

Title (en)

GPCRS AS ANGIOGENESIS TARGETS

Title (de)

GPCRS ALS ANGIOGENESE-TARGETS

Title (fr)

RÉCEPTEURS GPCR UTILISÉS COMME CIBLES POUR L'ANGIOGENÈSE

Publication

EP 1996619 A4 20091118 (EN)

Application

EP 07750916 A 20070214

Priority

  • US 2007004114 W 20070214
  • US 77299106 P 20060214

Abstract (en)

[origin: WO2007095353A2] The invention provides methods of modulating angiogenesis by increasing or decreasing expression or function of G-Protein Coupled Receptors (GPCRs) namely Lectomedin-3 (LEC3), Endothelin-1 Receptor (EDNRA) and C-X-C Chemokine Receptor 4 (CXCR-4). The invention also provides methods of inhibiting and promoting GPCR-dependent angiogenesis in vertebrates, particular mammals, including humans, for the treatment of angiogenesis-related diseases. The invention also provides methods of identifying compounds that promote or inhibit angiogenesis through their interaction with LEC3, EDNRA and/or CXCR-4. The invention further provides methods of modulating angiogenesis through the modulation of these GPCRs and VEGF.

IPC 8 full level

C07H 21/02 (2006.01); A61K 48/00 (2006.01)

CPC (source: EP)

A61P 1/04 (2017.12); A61P 9/10 (2017.12); A61P 17/00 (2017.12); A61P 17/06 (2017.12); A61P 19/00 (2017.12); A61P 19/02 (2017.12); A61P 27/02 (2017.12); A61P 29/00 (2017.12); A61P 33/00 (2017.12); A61P 35/00 (2017.12); C07K 14/7158 (2013.01); C07K 14/723 (2013.01); A01K 2227/105 (2013.01); A01K 2267/0306 (2013.01); A61K 38/00 (2013.01); A61K 48/00 (2013.01)

Citation (search report)

  • [XA] WO 02079492 A2 20021010 - EOS BIOTECHNOLOGY INC [US]
  • [XA] US 2002107195 A1 20020808 - GUPTA SHALLEY K [US]
  • [A] WO 9947158 A2 19990923 - UNIV BRITISH COLUMBIA [CA], et al
  • [A] WO 9728258 A1 19970807 - NAT INST HEALTH [US]
  • [A] WO 0052039 A2 20000908 - ICOS CORP [US]
  • [A] WO 2004075835 A2 20040910 - GENENTECH INC [US], et al
  • [A] HEIDEMANN JAN ET AL: "Mucosal angiogenesis regulation by CXCR4 and its ligand CXCL12 expressed by human intestinal microvascular endothelial cells.", AMERICAN JOURNAL OF PHYSIOLOGY. GASTROINTESTINAL AND LIVER PHYSIOLOGY JUN 2004, vol. 286, no. 6, June 2004 (2004-06-01), pages G1059 - G1068, XP002548626, ISSN: 0193-1857
  • [A] KAHN JOY ET AL: "Overexpression of CXCR4 on human CD34+ progenitors increases their proliferation, migration, and NOD/SCID repopulation.", BLOOD 15 APR 2004, vol. 103, no. 8, 15 April 2004 (2004-04-15), pages 2942 - 2949, XP002548627, ISSN: 0006-4971
  • [A] BAGNATO ANNA; CIRILLI ALESSIA; SALANI DEBORA; SIMEONE PAOLA; MULLER ANTONIO; NICOTRA MARIA RITA; NATALI PIER GIORGIO; VENUTI ALDO: "Growth inhibition of cervix carcinoma cells in vivo by endothelin A receptor blockade.", CANCER RESEARCH 15 NOV 2002, vol. 62, no. 22, 15 November 2002 (2002-11-15), pages 6381 - 6384, XP002548798, ISSN: 0008-5472
  • See references of WO 2007095353A2

Designated contracting state (EPC)

AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR

DOCDB simple family (publication)

WO 2007095353 A2 20070823; WO 2007095353 A3 20090416; EP 1996619 A2 20081203; EP 1996619 A4 20091118; JP 2009526861 A 20090723

DOCDB simple family (application)

US 2007004114 W 20070214; EP 07750916 A 20070214; JP 2008555380 A 20070214