EP 1998760 A2 20081210 - NON PEPTIDIC MOLECULES FOR DETECTING AND TREATING TUMORS
Title (en)
NON PEPTIDIC MOLECULES FOR DETECTING AND TREATING TUMORS
Title (de)
NICHT-PEPTIDISCHE MOLEKÜLE ZUR ERKENNUNG UND BEHANDLUNG VON TUMOREN
Title (fr)
COMPOSITIONS OUTILS ONCOLOGIQUES ET PROCÉDÉS D'UTILISATION POUR DÉTECTER ET TRAITER DES TUMEURS
Publication
Application
Priority
- US 2007008215 W 20070330
- US 39548706 A 20060330
- US 44949506 A 20060607
- US 44950806 A 20060607
Abstract (en)
[origin: WO2007117398A2] One of the most universal characteristics of malignant tumors is their acidity. Onco-tools are small non-peptide synthetic molecules designed to exploit this acidity for early detection and destruction of tumors. Each onco-tool has a structure which is anionic and hydrophilic at pH 7.4 and so repels from the negatively-charged surfaces of cells in normal tissues. When an onco-tool enters an acidic environment, such as in a tumor, a portion of the onco-tool molecules switch to their non-ionic lipophilic form which is designed to enter cells, such as cells in acidic areas of tumors. Prior to use of an onco-tool, a selected radioisotope is linked to the onco-tool. If that radioisotope emits radiation which can be detected outside the body, then the onco-tool can serve for detecting tumors. If that radioisotope emits radiation effective to kill cells, then the onco-tool can serve for treating tumors.
IPC 8 full level
A61K 31/16 (2006.01); A61K 31/185 (2006.01); A61P 35/00 (2006.01); A61P 43/00 (2006.01)
CPC (source: EP)
A61K 31/198 (2013.01); A61K 31/20 (2013.01); A61K 31/44 (2013.01); A61P 35/00 (2017.12); A61P 43/00 (2017.12)
Citation (search report)
See references of WO 2007117398A2
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR
Designated extension state (EPC)
AL BA HR MK RS
DOCDB simple family (publication)
WO 2007117398 A2 20071018; WO 2007117398 A3 20071206; WO 2007117398 B1 20080207; AU 2007235575 A1 20071018; CA 2647502 A1 20071018; EP 1998760 A2 20081210; JP 2009536152 A 20091008; MX 2008012282 A 20081112
DOCDB simple family (application)
US 2007008215 W 20070330; AU 2007235575 A 20070330; CA 2647502 A 20070330; EP 07754699 A 20070325; JP 2009503073 A 20070330; MX 2008012282 A 20070330