EP 1999111 A2 20081210 - MONOCYCLIC AND BICYCLIC HIMBACINE DERIVATIVES USEFUL AS THROMBIN RECEPTOR ANTAGONISTS
Title (en)
MONOCYCLIC AND BICYCLIC HIMBACINE DERIVATIVES USEFUL AS THROMBIN RECEPTOR ANTAGONISTS
Title (de)
MONOZYKLISCHE UND BIZYKLISCHE HIMBACIN-DERIVATE ALS THROMBIN-REZEPTOR-ANTAGONISTEN
Title (fr)
DÉRIVÉS D'HIMBACINE MONOCYCLIQUES ET BICYCLI QUES UTILES EN TANT QU'ANTAGONISTES DU RÉCEPTEUR DE LA THROMBINE
Publication
Application
Priority
- US 2007007497 W 20070327
- US 78696106 P 20060329
Abstract (en)
[origin: US2007232635A1] Monocyclic and bicyclic himbacine derivatives of the formula or a pharmaceutically acceptable salt or solvate of said compound wherein <img id="CUSTOM-CHARACTER-00001" he="1.78mm" wi="6.35mm" file="US20070232635A1-20071004-P00001.TIF" alt="custom-character" img-content="character" img-format="tif"/> represents an optional double bond and wherein G<SUB>n</SUB>, J<SUB>n</SUB>, R<SUP>3</SUP>, R<SUP>8</SUP>, R<SUP>9</SUP>, R<SUP>10</SUP>, R<SUP>11</SUP>, R<SUP>32</SUP>, R<SUP>33</SUP>, B and Het are herein defined are disclosed, as well as pharmaceutical compositions containing them and a method of treating diseases associated with thrombosis, atherosclerosis, restenosis, hypertension, angina pectoris, arrhythmia, heart failure, and cancer by administering said compounds. Combination therapy with other agents is also claimed.
IPC 8 full level
A61K 31/44 (2006.01); A61P 9/00 (2006.01); A61P 29/00 (2006.01); C07D 213/24 (2006.01)
CPC (source: EP KR US)
A61K 31/44 (2013.01 - KR); A61P 1/00 (2017.12 - EP); A61P 1/02 (2017.12 - EP); A61P 1/04 (2017.12 - EP); A61P 1/16 (2017.12 - EP); A61P 3/10 (2017.12 - EP); A61P 7/02 (2017.12 - EP); A61P 7/04 (2017.12 - EP); A61P 9/00 (2017.12 - EP); A61P 9/04 (2017.12 - EP); A61P 9/06 (2017.12 - EP); A61P 9/10 (2017.12 - EP); A61P 9/12 (2017.12 - EP); A61P 11/00 (2017.12 - EP); A61P 11/06 (2017.12 - EP); A61P 13/10 (2017.12 - EP); A61P 13/12 (2017.12 - EP); A61P 15/10 (2017.12 - EP); A61P 17/06 (2017.12 - EP); A61P 19/02 (2017.12 - EP); A61P 19/10 (2017.12 - EP); A61P 25/00 (2017.12 - EP); A61P 25/06 (2017.12 - EP); A61P 25/28 (2017.12 - EP); A61P 27/02 (2017.12 - EP); A61P 27/06 (2017.12 - EP); A61P 29/00 (2017.12 - EP); A61P 35/00 (2017.12 - EP); A61P 37/02 (2017.12 - EP); A61P 39/00 (2017.12 - EP); A61P 43/00 (2017.12 - EP); C07D 213/24 (2013.01 - EP KR US); C07D 213/57 (2013.01 - EP US); C07D 405/06 (2013.01 - EP US)
Citation (search report)
See references of WO 2007126771A2
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR
Designated extension state (EPC)
AL BA HR MK RS
DOCDB simple family (publication)
US 2007232635 A1 20071004; US 7888377 B2 20110215; AR 060095 A1 20080521; AU 2007243657 A1 20071108; CA 2647933 A1 20071108; CN 101460463 A 20090617; EP 1999111 A2 20081210; EP 1999111 B1 20131218; JP 2009534308 A 20090924; KR 20080104352 A 20081202; MX 2008012574 A 20081010; TW 200811107 A 20080301; WO 2007126771 A2 20071108; WO 2007126771 A3 20071221; ZA 200808247 B 20091125
DOCDB simple family (application)
US 72867207 A 20070327; AR P070101263 A 20070327; AU 2007243657 A 20070327; CA 2647933 A 20070327; CN 200780020280 A 20070327; EP 07754070 A 20070327; JP 2009502927 A 20070327; KR 20087023799 A 20080929; MX 2008012574 A 20070327; TW 96110838 A 20070328; US 2007007497 W 20070327; ZA 200808247 A 20080926