EP 1999138 A1 20081210 - NOVEL AMPHIPHILIC DERIVATIVES OF ALPHA-C-PHENYL-N-TERT-BUTYLNITRONE
Title (en)
NOVEL AMPHIPHILIC DERIVATIVES OF ALPHA-C-PHENYL-N-TERT-BUTYLNITRONE
Title (de)
NEUE AMPHIPHILE DERIVATE VON ALPHA-C-PHENYL-N-TERT.-BUTYLNITRON
Title (fr)
NOUVEAUX DERIVES AMPHIPHILES DE L'ALPHA-C-PHENYL-N-TERT-BUTYL NITRONE
Publication
Application
Priority
- FR 2007000446 W 20070315
- FR 0602355 A 20060317
Abstract (en)
[origin: FR2898602A1] alpha -C-Phenyl-N-tert butyl nitrone amphiphilic derivatives (I), are new. alpha -C-Phenyl-N-tert-butyl nitrone amphiphilic derivatives of formula (I), are new. X : hydrophilic group like mono-/polysaccharide e.g. amino derivative of mono-/polysaccharide, polyethylene oxide chain, peptide chain, polar ionic group like quaternary ammonium-, amine oxide-, carnitine-, phosphate- or choline group; m : 1-3; Y 1a spacer or a linker like ester, amide, urea, urethane, (thio)ether, amine, 1-6C hydrocarbon (optionally interrupted by a ester, amide, urea, urethane, ether amine or thio-ether); Y 2ester-, amide-, urea-, urethane-, thio-ether-, amino acid- or serinol group; m1 : 1-2; and n : 0-2; X 1H or 4-14C alkyl (optionally substituted by F). An independent claim is included for the preparation of (I). [Image] ACTIVITY : Immunostimulant; Tranquilizer; Antiinflammatory; Vasotropic; Antiarteriosclerotic; Neuroprotective; Nootropic; Antiparkinsonian; Antiemetic; Cytostatic; Anticonvulsant. MECHANISM OF ACTION : None given.
IPC 8 full level
C07H 15/12 (2006.01)
CPC (source: EP US)
A61K 8/40 (2013.01 - EP US); A61K 8/416 (2013.01 - EP US); A61K 8/42 (2013.01 - EP US); A61K 8/466 (2013.01 - EP US); A61K 8/55 (2013.01 - EP US); A61P 9/00 (2017.12 - EP); A61P 9/10 (2017.12 - EP); A61P 17/18 (2017.12 - EP); A61P 25/00 (2017.12 - EP); A61P 25/14 (2017.12 - EP); A61P 25/16 (2017.12 - EP); A61P 25/28 (2017.12 - EP); A61P 29/00 (2017.12 - EP); A61P 35/00 (2017.12 - EP); A61P 37/00 (2017.12 - EP); A61P 37/02 (2017.12 - EP); A61P 37/06 (2017.12 - EP); A61P 39/06 (2017.12 - EP); A61Q 19/08 (2013.01 - EP US); C07H 15/12 (2013.01 - EP US); C07H 15/18 (2013.01 - EP US); A61K 2800/522 (2013.01 - EP US)
Citation (search report)
See references of WO 2007118947A1
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR
DOCDB simple family (publication)
FR 2898602 A1 20070921; FR 2898602 B1 20120622; CN 101421288 A 20090429; EP 1999138 A1 20081210; JP 2009530252 A 20090827; RU 2008141144 A 20100427; US 2009306001 A1 20091210; US 8173843 B2 20120508; WO 2007118947 A1 20071025
DOCDB simple family (application)
FR 0602355 A 20060317; CN 200780013106 A 20070315; EP 07731140 A 20070315; FR 2007000446 W 20070315; JP 2008558852 A 20070315; RU 2008141144 A 20070315; US 28275507 A 20070315