EP 2002714 A1 20081217 - Novel gene disruptions, compositions and methods relating thereto

Title (en)

Novel gene disruptions, compositions and methods relating thereto

Title (de)

Neuartige Genunterbrechung, dazugehörige Zusammensetzungen und Verfahren

Title (fr)

Nouvelles ruptures génétiques, compositions et procédés associés à celles-ci

Publication

EP 2002714 A1 20081217 (EN)

Application

EP 08012287 A 20061116

Priority

EP 06849173 A 20061116
US 73910505 P 20051121

Abstract (en)

The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO218, PRO228, PRO271, PRO273, PRO295, PRO302, PRO305, PRO326, PRO386, PRO655, PRO162, PRO788, PRO792, PRO940, PRO941, PRO1004, PRO1012, PRO1016, PRO474, PRO5238, PRO1069 PRO1111, PRO1113, PRO1130, PRO1195, PRO1271, PRO1865, PRO1879, PRO3446, PRO3543, PRO4329, PRO4352, PRO5733, PRO9859, PRO9864, PRO9904, PRO9907, PRO10013, PRO90948, PRO28694, PRO16089, PRO19563, PRO19675, PRO20084, PRO21434, PRO50332, PRO38465 or PRO346 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.

IPC 8 full level

A01K 67/027 (2006.01); A61K 49/00 (2006.01)

CPC (source: EP US)

A01K 67/0276 (2013.01 - EP US); A61K 49/0008 (2013.01 - EP US); A61P 1/04 (2017.12 - EP); A61P 1/16 (2017.12 - EP); A61P 3/00 (2017.12 - EP); A61P 3/06 (2017.12 - EP); A61P 3/10 (2017.12 - EP); A61P 7/02 (2017.12 - EP); A61P 9/00 (2017.12 - EP); A61P 9/04 (2017.12 - EP); A61P 9/10 (2017.12 - EP); A61P 9/12 (2017.12 - EP); A61P 9/14 (2017.12 - EP); A61P 11/06 (2017.12 - EP); A61P 13/12 (2017.12 - EP); A61P 17/06 (2017.12 - EP); A61P 19/00 (2017.12 - EP); A61P 19/02 (2017.12 - EP); A61P 19/08 (2017.12 - EP); A61P 19/10 (2017.12 - EP); A61P 21/00 (2017.12 - EP); A61P 25/00 (2017.12 - EP); A61P 25/16 (2017.12 - EP); A61P 25/18 (2017.12 - EP); A61P 25/22 (2017.12 - EP); A61P 25/24 (2017.12 - EP); A61P 25/28 (2017.12 - EP); A61P 27/02 (2017.12 - EP); A61P 27/12 (2017.12 - EP); A61P 29/00 (2017.12 - EP); A61P 35/00 (2017.12 - EP); A61P 37/02 (2017.12 - EP); A61P 37/06 (2017.12 - EP); A61P 37/08 (2017.12 - EP); C12N 15/8509 (2013.01 - EP US); C12Q 1/6883 (2013.01 - EP US); A01K 2217/075 (2013.01 - EP US); A01K 2227/105 (2013.01 - EP US); A01K 2267/03 (2013.01 - EP US); C12Q 2600/158 (2013.01 - EP US)

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Citation (search report)

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Designated contracting state (EPC)

AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR

Designated extension state (EPC)

AL BA HR MK RS

DOCDB simple family (publication)

DOCDB simple family (application)

US 2006060990 W 20061116; AU 2006335053 A 20061116; CA 2630432 A 20061116; EP 06849173 A 20061116; EP 08012287 A 20061116; JP 2008541480 A 20061116; US 201113040049 A 20110303; US 81441306 A 20061116; ZA 200804162 A 20061116; ZA 200904165 A 20090615; ZA 200904179 A 20090615; ZA 200904180 A 20090615; ZA 200904181 A 20090615; ZA 200904182 A 20090615; ZA 200904183 A 20090615; ZA 200904184 A 20090615; ZA 200904186 A 20090615; ZA 200904187 A 20090615; ZA 200904188 A 20090615; ZA 200904189 A 20090615