EP 2004207 A1 20081224 - ACTIVE SUBSTANCE FRACTIONS FOR FORMULATIONS FOR THE THERAPY AND PROPHYLAXIS OF INFLAMMATORY DISEASES
Title (en)
ACTIVE SUBSTANCE FRACTIONS FOR FORMULATIONS FOR THE THERAPY AND PROPHYLAXIS OF INFLAMMATORY DISEASES
Title (de)
WIRKSTOFFFRAKTIONEN FÜR FORMULIERUNGEN ZUR THERAPIE UND PRÄVENTION VON ENTZÜNDLICHEN ERKRANKUNGEN
Title (fr)
FRACTIONS DE PRINCIPE ACTIF DESTINÉES À DES FORMULATIONS POUR LE TRAITEMENT ET LA PRÉVENTION DE MALADIES INFLAMMATOIRES
Publication
Application
Priority
- DE 2007000579 W 20070330
- DE 102006015574 A 20060403
Abstract (en)
[origin: DE102006015574A1] Active substance fraction from Rheum species, to treat and prevent e.g. inflammatory diseases, where the preparation of active substance fraction comprises: extracting dried and ground root samples with methanol; separating lipophilic material from the formed aqueous phase; agitating the purified aqueous phase with ethylacetate; column chromatographically separating the resulting aqueous phase and the combined ethylacetate phase to a limited number of active substance fractions; and condensing the active substance fraction with same content spectrum. Active substance fraction from Rheum species for treating and preventing inflammatory or autoimmune disorder and/or diseases associated with keratinocyte proliferation disturbances, where the preparation of active substance fraction comprises: extracting dried and ground root samples with methanol; separating lipophilic material from the formed aqueous phase under complete removal of methanol; agitating the purified aqueous phase with ethylacetate; separately processing the resulting aqueous phase and the combined ethylacetate phase; column chromatographically separating the resulting aqueous phase and the combined ethylacetate phase to a limited number of active substance fractions; and condensing the active substance fraction with same content spectrum. ACTIVITY : Antiinflammatory; Immunosuppressive; Antiarthritic; Antirheumatic; Gastrointestinal-Gen; Antiulcer; Antipsoriatic; Dermatological; Antimicrobial; Vulnerary. MECHANISM OF ACTION : Interleukin (IL)-1beta and/or IL-2-mRNA-expression inducer; Transforming growth factor (TGF)-beta 1 inducer; IL-1beta or IL-2 suppressor. The ability of the active substance fraction to modulate IL-2-mRNA expression of human phytohaemagglutinin stimulated mononuclear cell. The result showed that the active substance fraction significantly induced the IL-2-mRNA-expression.
IPC 8 full level
A61K 36/70 (2006.01)
CPC (source: EP)
A61K 36/70 (2013.01); A61K 36/708 (2013.01); A61P 37/00 (2017.12)
Citation (search report)
See references of WO 2007112730A1
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR
DOCDB simple family (publication)
DE 102006015574 A1 20071004; EP 2004207 A1 20081224; WO 2007112730 A1 20071011
DOCDB simple family (application)
DE 102006015574 A 20060403; DE 2007000579 W 20070330; EP 07722137 A 20070330