EP 2004236 A2 20081224 - LIPID BASED DRUG DELIVERY SYSTEMS COMPRISING PHOSPHOLIPASE A2 DEGRADABLE LIPIDS THAT PERFORM AN INTRAMOLECULAR CYCLIZATION REACTION UPON HYDROLYSIS
Title (en)
LIPID BASED DRUG DELIVERY SYSTEMS COMPRISING PHOSPHOLIPASE A2 DEGRADABLE LIPIDS THAT PERFORM AN INTRAMOLECULAR CYCLIZATION REACTION UPON HYDROLYSIS
Title (de)
ARZNEIABGABESYSTEME AUF LIPIDBASIS MIT PHOSPHOLIPASE-A2-ABBAUBAREN LIPIDEN, DIE UNTER HYDROLYSE EINE INTRAMOLEKULARE CYCLISIERUNGSREAKTION DURCHFÜHREN
Title (fr)
SYSTÈMES DE DÉLIVRANCE DE MÉDICAMENTS À BASE DE LIPIDES CONTENANT DES LIPIDES DÉGRADABLES PAR LA PHOSPHOLIPASE A2 QUI PRODUISENT UNE RÉACTION DE CYCLISATION INTRAMOLÉCULAIRE LORS DE L'HYDROLYSE
Publication
Application
Priority
- DK 2007000143 W 20070323
- DK PA200600411 A 20060323
Abstract (en)
[origin: WO2007107161A2] The present invention relates to a lipid-based drug delivery system for administration of anti-cancer drugs in a prodrug form, said prodrug furthermore being a substrate for extracellular phospholipase A2 to the extent that an organic radical can be hydrolytically cleaved off, resulting in an intramolecular reaction, said system comprising lipopolymers and/or glycolipids so as to present hydrophilic chains on the surface of the system. In addition, the lipid prodrug and drug carries can be used in combination with incorporated drugs. Pharmaceutical compositions comprising the drug delivery system can be used in diagnosis and targeted treatment of various disorders, e.g. cancer, infectious, and inflammatory conditions, etc., i.e. disorders and diseases associated with or resulting from increased levels of extracellular PLA<SUB>2</SUB> activity in the diseased tissue.
IPC 8 full level
A61K 47/48 (2006.01); A61P 29/00 (2006.01); A61P 31/00 (2006.01); A61P 35/00 (2006.01)
CPC (source: EP)
A61K 47/544 (2017.07); A61K 47/555 (2017.07); A61K 47/6911 (2017.07); A61P 29/00 (2017.12); A61P 31/00 (2017.12); A61P 35/00 (2017.12); A61P 35/02 (2017.12); A61P 43/00 (2017.12)
Citation (search report)
See references of WO 2007107161A2
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR
Designated extension state (EPC)
AL BA HR MK RS
DOCDB simple family (publication)
WO 2007107161 A2 20070927; WO 2007107161 A3 20080410; WO 2007107161 A8 20071122; AU 2007229160 A1 20070927; CA 2647779 A1 20070927; EP 2004236 A2 20081224; JP 2009530318 A 20090827
DOCDB simple family (application)
DK 2007000143 W 20070323; AU 2007229160 A 20070323; CA 2647779 A 20070323; EP 07711285 A 20070323; JP 2009500701 A 20070323