EP 2004727 A1 20081224 - SOL-GEL DERIVED SILICA POLYMERS FOR THE SUSTAINED RELEASE OF PROTEINS
Title (en)
SOL-GEL DERIVED SILICA POLYMERS FOR THE SUSTAINED RELEASE OF PROTEINS
Title (de)
NACH DEM SOL-GEL-VERFAHREN HERGESTELLTE SILICIUMDIOXIDPOLYMERE ZUR GLEICHMÄSSIG HINHALTENDEN FREISETZUNG VON PROTEINEN
Title (fr)
POLYMÈRES DE SILICE DÉRIVÉS DE SOL-GEL POUR LA LIBÉRATION PROLONGÉE DE PROTÉINES
Publication
Application
Priority
- EP 2007051762 W 20070223
- IT MI20060734 A 20060412
Abstract (en)
[origin: WO2007115860A1] The use of wet silica based polymers obtained by the sol-gel technology for the entrapment and sustained release of macromolecular bioactive compounds and, more specifically, proteins with pharmaceutical applications, is disclosed. The wet-gel formulations are obtained by a method which comprises mixing an alkoxysilane solution, a gelling catalyst and a buffered water solution of a biologically active principle and subsequently casting the thus-obtained mixture into suitable containers without previous or subsequent partial or complete removal of the water solvent; the containers are then sealed after casting in order to preserve the wet state of the gel. The wet-gel formulations may then be used for the manufacture of a ready-to-use injectable solution by mixing the silica wet-gel formulation with water or with a physiological water solution.
IPC 8 full level
C08G 77/02 (2006.01)
CPC (source: EP)
C08G 77/02 (2013.01)
Citation (search report)
See references of WO 2007115860A1
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 2007115860 A1 20071018; EP 2004727 A1 20081224; IT MI20060734 A1 20071013; JP 2009533373 A 20090917
DOCDB simple family (application)
EP 2007051762 W 20070223; EP 07712309 A 20070223; IT MI20060734 A 20060412; JP 2009504660 A 20070223