EP 2016058 B1 20160106 - INHIBITORS OF C-FMS KINASE
Title (en)
INHIBITORS OF C-FMS KINASE
Title (de)
INHIBITOREN VON C-FMS-KINASE
Title (fr)
INHIBITEURS DE LA KINASE DE C-FMS
Publication
Application
Priority
- US 2007066875 W 20070418
- US 79366706 P 20060420
Abstract (en)
[origin: US2007249608A1] The invention is directed to compounds of Formula I: wherein Z, X, J, R<SUP>2 </SUP>and W are set forth in the specification, as well as solvates, hydrates, tautomers and pharmaceutically acceptable salts thereof, that inhibit protein tyrosine kinases, especially c-fms kinase. Methods of treating autoimmune diseases; and diseases with an inflammatory component; treating metastasis from ovarian cancer, uterine cancer, breast cancer, prostate cancer, lung cancer, colon cancer, stomach cancer, hairy cell leukemia; and treating pain, including skeletal pain caused by tumor metastasis or osteoarthritis, or visceral, inflammatory, and neurogenic pain; as well as osteoporosis, Paget's disease, and other diseases in which bone resorption mediates morbidity including rheumatoid arthritis, and other forms of inflammatory arthritis, osteoarthritis, prosthesis failure, osteolytic sarcoma, myeloma, and tumor metastasis to bone with the compounds of Formula I, are also provided.
IPC 8 full level
A61K 31/4172 (2006.01); A61K 31/437 (2006.01); A61K 31/5377 (2006.01); A61P 11/00 (2006.01); A61P 13/00 (2006.01); A61P 35/00 (2006.01); C07D 207/34 (2006.01); C07D 233/90 (2006.01); C07D 401/12 (2006.01); C07D 401/14 (2006.01); C07D 403/12 (2006.01); C07D 405/12 (2006.01); C07D 405/14 (2006.01); C07D 409/12 (2006.01); C07D 413/12 (2006.01); C07D 413/14 (2006.01); C07D 493/08 (2006.01); C12N 9/99 (2006.01)
CPC (source: EP KR US)
A61K 31/4178 (2013.01 - KR); A61P 1/02 (2017.12 - EP); A61P 1/04 (2017.12 - EP); A61P 1/18 (2017.12 - EP); A61P 3/10 (2017.12 - EP); A61P 7/00 (2017.12 - EP); A61P 9/00 (2017.12 - EP); A61P 9/10 (2017.12 - EP); A61P 9/14 (2017.12 - EP); A61P 11/00 (2017.12 - EP); A61P 11/06 (2017.12 - EP); A61P 13/00 (2017.12 - EP); A61P 13/12 (2017.12 - EP); A61P 17/06 (2017.12 - EP); A61P 19/02 (2017.12 - EP); A61P 19/08 (2017.12 - EP); A61P 19/10 (2017.12 - EP); A61P 25/00 (2017.12 - EP); A61P 25/04 (2017.12 - EP); A61P 25/18 (2017.12 - EP); A61P 25/28 (2017.12 - EP); A61P 27/02 (2017.12 - EP); A61P 29/00 (2017.12 - EP); A61P 31/04 (2017.12 - EP); A61P 31/18 (2017.12 - EP); A61P 35/00 (2017.12 - EP); A61P 35/02 (2017.12 - EP); A61P 35/04 (2017.12 - EP); A61P 37/00 (2017.12 - EP); A61P 37/02 (2017.12 - EP); A61P 37/06 (2017.12 - EP); A61P 43/00 (2017.12 - EP); C07D 207/34 (2013.01 - EP US); C07D 233/90 (2013.01 - EP US); C07D 401/12 (2013.01 - EP US); C07D 401/14 (2013.01 - EP US); C07D 403/12 (2013.01 - EP US); C07D 405/12 (2013.01 - EP KR US); C07D 405/14 (2013.01 - EP US); C07D 409/12 (2013.01 - EP US); C07D 413/12 (2013.01 - EP US); C07D 413/14 (2013.01 - EP KR US); C07D 493/08 (2013.01 - EP US); C12N 9/99 (2013.01 - EP US)
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR
Designated extension state (EPC)
AL BA HR MK RS
DOCDB simple family (publication)
US 2007249608 A1 20071025; US 8815867 B2 20140826; AR 060610 A1 20080702; AR 060611 A1 20080702; AR 060612 A1 20080702; AU 2007240440 A1 20071101; AU 2007240440 B2 20120920; AU 2007240442 A1 20071101; AU 2007240442 B2 20120906; AU 2007240443 A1 20071101; AU 2007240443 B2 20121101; BR PI0710548 A2 20120605; BR PI0710548 B1 20200324; BR PI0710548 B8 20210525; CA 2649739 A1 20071101; CA 2649739 C 20150901; CA 2649924 A1 20071101; CA 2649924 C 20140819; CA 2650057 A1 20071101; CA 2650057 C 20140729; CN 101472914 A 20090701; CN 101472914 B 20150520; EP 2016058 A1 20090121; EP 2016058 B1 20160106; EP 2016070 A1 20090121; EP 2016070 B1 20160113; EP 2016074 A1 20090121; EP 2016074 B1 20160113; ES 2564781 T3 20160329; ES 2565238 T3 20160401; ES 2566772 T3 20160415; HK 1133878 A1 20100409; IL 194845 A0 20090803; IL 194845 A 20141130; JP 2009534405 A 20090924; JP 2009534406 A 20090924; JP 2009534407 A 20090924; JP 5331679 B2 20131030; JP 5331680 B2 20131030; JP 5331681 B2 20131030; KR 101367646 B1 20140227; KR 101406877 B1 20140613; KR 101491564 B1 20150209; KR 20080110917 A 20081219; KR 20090003343 A 20090109; KR 20090015066 A 20090211; MX 2008013529 A 20090115; MX 2008013530 A 20090114; MX 2008013531 A 20090120; NO 20084896 L 20090112; NZ 572070 A 20110930; NZ 572071 A 20111222; NZ 572072 A 20110930; PE 20080074 A1 20080211; RU 2008145763 A 20100527; RU 2475483 C2 20130220; SG 171593 A1 20110629; TW 200806659 A 20080201; TW 200815414 A 20080401; TW 200815415 A 20080401; TW I411612 B 20131011; UA 93085 C2 20110110; US 2007249680 A1 20071025; US 2007249685 A1 20071025; US 2014200245 A1 20140717; US 2014329815 A1 20141106; US 2014378457 A1 20141225; US 2016122334 A1 20160505; US 8722718 B2 20140513; US 8859602 B2 20141014; US 9266866 B2 20160223; US 9394289 B2 20160719; US 9403804 B2 20160802; UY 30297 A1 20070831; WO 2007124319 A1 20071101; WO 2007124321 A1 20071101; WO 2007124322 A1 20071101; ZA 200809873 B 20100224
DOCDB simple family (application)
US 73665307 A 20070418; AR P070101691 A 20070419; AR P070101692 A 20070419; AR P070101693 A 20070419; AU 2007240440 A 20070418; AU 2007240442 A 20070418; AU 2007240443 A 20070418; BR PI0710548 A 20070418; CA 2649739 A 20070418; CA 2649924 A 20070418; CA 2650057 A 20070418; CN 200780023190 A 20070418; EP 07760840 A 20070418; EP 07760842 A 20070418; EP 07760846 A 20070418; ES 07760840 T 20070418; ES 07760842 T 20070418; ES 07760846 T 20070418; HK 09112210 A 20091228; IL 19484508 A 20081022; JP 2009506741 A 20070418; JP 2009506742 A 20070418; JP 2009506744 A 20070418; KR 20087028189 A 20070418; KR 20087028212 A 20070418; KR 20087028261 A 20070418; MX 2008013529 A 20070418; MX 2008013530 A 20070418; MX 2008013531 A 20070418; NO 20084896 A 20081120; NZ 57207007 A 20070418; NZ 57207107 A 20070418; NZ 57207207 A 20070418; PE 2007000480 A 20070418; RU 2008145763 A 20070418; SG 2011028305 A 20070418; TW 96113730 A 20070419; TW 96113731 A 20070419; TW 96113732 A 20070419; UA A200813399 A 20070418; US 2007066868 W 20070418; US 2007066870 W 20070418; US 2007066875 W 20070418; US 201414210920 A 20140314; US 201414336014 A 20140721; US 201414480944 A 20140909; US 201614995644 A 20160114; US 73664407 A 20070418; US 73665007 A 20070418; UY 30297 A 20070419; ZA 200809873 A 20081119