Title (en)

METHODS OF IDENTIFYING SMALL MOLECULES FOR RENEWAL, SURVIVAL AND MIGRATION OF CARDIAC PROGENITORS

Title (de)

VERFAHREN ZUR IDENTIFIKATION KLEINER MOLEKÜLE ZUR ERNEUERUNG, BEWAHRUNG UND VERSCHIEBUNG VON HERZVORLÄUFERZELLEN

Title (fr)

METHODES D'IDENTIFICATION DE PETITES MOLECULES POUR LE RENOUVELLEMENT, LA SURVIE ET LA MIGRATION DE CELLULES SOUCHES CARDIAQUES

Publication

EP 2019966 A2 20090204 (EN)

Application

EP 07794499 A 20070502

Priority

• US 2007010684 W 20070502
• US 79733806 P 20060502

Abstract (en)

[origin: WO2007130487A2] The present invention relates to a small molecule high-throughput screening assay consisting of detectably labeled cardiac progenitor cells. The invention also describes a method of identifying small molecules from the high-throughput assay affecting cardiogenesis and/or modulating cardiac progenitor cell development. Also described are methods of stimulating maturation of cardiac progenitor cells using a GSK-3ß inhibitor.

IPC 8 full level

G01N 33/567 (2006.01); C12N 5/00 (2006.01); C12N 15/00 (2006.01); G01N 33/50 (2006.01); G01N 33/53 (2006.01); G01N 33/74 (2006.01)

CPC (source: EP)

A01K 67/0275 (2013.01); A61K 49/0008 (2013.01); C07K 14/4702 (2013.01); G01N 33/5073 (2013.01); G01N 33/743 (2013.01); A01K 2217/052 (2013.01); A01K 2217/072 (2013.01); A01K 2217/203 (2013.01); A01K 2217/206 (2013.01); A01K 2227/105 (2013.01); A01K 2267/0375 (2013.01); C12N 2800/30 (2013.01); C12N 2840/203 (2013.01); G01N 2333/723 (2013.01); G01N 2500/10 (2013.01)

Designated contracting state (EPC)

AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR

Designated extension state (EPC)

AL BA HR MK RS

DOCDB simple family (publication)

WO 2007130487 A2 20071115; WO 2007130487 A3 20080228; AU 2007248622 A1 20071115; CA 2651101 A1 20071115; EP 2019966 A2 20090204; EP 2019966 A4 20100113

DOCDB simple family (application)

US 2007010684 W 20070502; AU 2007248622 A 20070502; CA 2651101 A 20070502; EP 07794499 A 20070502