Global Patent Index - EP 2023923 A2

EP 2023923 A2 2009-02-18 - USE OF IXABEPILONE IN COMBINATION WITH CYP3A4 INHIBITORS FOR PHARMACEUTICALS

Title (en)

USE OF IXABEPILONE IN COMBINATION WITH CYP3A4 INHIBITORS FOR PHARMACEUTICALS

Title (de)

VERWENDUNG VON IXABEPILON IN KOMBINATION MIT CYP3A4-HEMMERN FÜR ARZNEIMITTEL

Title (fr)

UTILISATION DE L'IXABÉPILONE EN COMBINAISON AVEC DES INHIBITEURS DU CYP3A4 EN TANT QUE PRODUITS PHARMACEUTIQUES

Publication

EP 2023923 A2 (EN)

Application

EP 07784137 A

Priority

  • US 2007069741 W
  • US 80319306 P

Abstract (en)

[origin: WO2007140299A2] Disclosed are Uses of ixabepilone in combination with CYP3A4 inhibitors such as ketoconazole and lapatinib to achieve a surprisingly enhanced pharmacological effect as compared with when ixabepilone is administered unaccompanied by the CYP3A4 inhibitor. Also disclosed are methods of treating cancer in a human patient comprising administering to the human a therapeutically-effective combination of an amount of a the CYP3A4 inhibitor and an amount of ixabepilone to achieve the enhanced pharmacological effect.

IPC 8 full level (invention and additional information)

A61K 31/427 (2006.01); A61K 31/496 (2006.01); A61K 31/517 (2006.01); A61K 35/00 (2006.01); A61K 45/06 (2006.01)

CPC (invention and additional information)

A61K 45/06 (2013.01); A61K 31/427 (2013.01); A61K 31/496 (2013.01); A61K 31/517 (2013.01)

Combination set (CPC)

  1. A61K 31/427 + A61K 2300/00
  2. A61K 31/496 + A61K 2300/00
  3. A61K 31/517 + A61K 2300/00

Citation (search report)

See references of WO 2007140299A3

Designated contracting state (EPC)

AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR

Designated extension state (EPC)

AL BA HR MK RS

EPO simple patent family

WO 2007140299 A2 20071206; WO 2007140299 A3 20080703; EP 2023923 A2 20090218

INPADOC legal status


2012-04-04 [18D] APPLICATION DEEMED TO BE WITHDRAWN

- Effective date: 20110910

2009-09-02 [DAX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT (TO ANY COUNTRY) (DELETED)

2009-04-22 [17Q] FIRST EXAMINATION REPORT

- Effective date: 20090324

2009-02-18 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20081205

2009-02-18 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A2

- Designated State(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR

2009-02-18 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO:

- Countries: AL BA HR MK RS