EP 2024391 A2 20090218 - CRYSTAL STRUCTURE OF CRIG AND C3B: CRIG COMPLEX
Title (en)
CRYSTAL STRUCTURE OF CRIG AND C3B: CRIG COMPLEX
Title (de)
KRISTALLSTRUKTUR FÜR CRIG UND C3B: CRIG-KOMPLEX
Title (fr)
STRUCTURE CRISTALLINE DE CRIg ET D'UN COMPLEXE C3b:CRIg
Publication
Application
Priority
- US 2007012816 W 20070530
- US 81027106 P 20060601
- US 80622506 P 20060629
- US 83936306 P 20060821
Abstract (en)
[origin: WO2008036135A2] The present invention concerns determination of the crystal structure of the macrophage specific receptor, CRIg (earlier referred to as STIgMA), and its complex with the C3b and C3c subunits of complement C3 (C3b:CRIg and C3c:CRIg complexes). The invention further concerns the use of the crystal structure of CRIg or the C3b:CRIg complex to screen for and identify molecules structurally and/or functionally related to CRIg, including CRIg agonists and antagonists.
IPC 8 full level
C07K 14/705 (2006.01); C30B 7/00 (2006.01); G01N 23/20 (2006.01); G06F 19/00 (2006.01)
CPC (source: EP)
A61P 29/00 (2017.12); A61P 43/00 (2017.12); C07K 14/70503 (2013.01); C30B 7/00 (2013.01); G01N 33/6863 (2013.01); C07K 2299/00 (2013.01); C07K 2319/30 (2013.01)
Citation (search report)
See references of WO 2008036135A2
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR
Designated extension state (EPC)
AL BA HR MK RS
DOCDB simple family (publication)
WO 2008036135 A2 20080327; WO 2008036135 A3 20081002; AU 2007297869 A1 20080327; AU 2007297869 A8 20090108; CA 2654438 A1 20080327; EP 2024391 A2 20090218; JP 2010505743 A 20100225
DOCDB simple family (application)
US 2007012816 W 20070530; AU 2007297869 A 20070530; CA 2654438 A 20070530; EP 07852376 A 20070530; JP 2009513268 A 20070530