Global Patent Index - EP 2026837 A4

EP 2026837 A4 20100602 - ANTIBODIES AS T CELL RECEPTOR MIMICS, METHODS OF PRODUCTION AND USES THEREOF

Title (en)

ANTIBODIES AS T CELL RECEPTOR MIMICS, METHODS OF PRODUCTION AND USES THEREOF

Title (de)

ANTIKÖRPER ALS T-ZELL-REZEPTOR-MIMICS, HERSTELLUNGSVERFAHREN UND IHRE VERWENDUNGEN

Title (fr)

ANTICORPS UTILES EN TANT QU'ANALOGUES DE RÉCEPTEUR DES LYMPHOCYTES T, LEURS PROCÉDÉS DE PRODUCTION ET LEURS UTILISATIONS

Publication

EP 2026837 A4 20100602 (EN)

Application

EP 07777355 A 20070601

Priority

  • US 2007012958 W 20070601
  • US 81007906 P 20060601
  • US 51751606 A 20060907

Abstract (en)

[origin: WO2007143104A2] The present invention relates to a methodology of producing antibodies that recognize peptides associated with a tumorigenic or disease state, wherein the peptides are displayed in the context of HLA molecules. These antibodies will mimic the specificity of a T cell receptor (TCR) but will have higher binding affinity such that the molecules may be used as therapeutic, diagnostic and research reagents. The method of producing a T-cell receptor mimic of the present invention includes identifying a peptide of interest, wherein the peptide of interest is capable of being presented by an MHC molecule. Then, an immunogen comprising at least one peptide/MHC complex is formed, wherein the peptide of the peptide/MHG complex is the peptide of interest. An effective amount of the immunogen is then administered to a host for eliciting an immune response, and serum collected from the host is assayed to determine if desired antibodies that recognize a three-dimensional presentation of the peptide in the binding groove of the MHC molecule are being produced. The desired antibodies can differentiate the peptide/MHC complex from the MHC molecule alone, the peptide alone, and a complex of MHC and irrelevant peptide. Finally, the desired antibodies are isolated.

IPC 8 full level

A61K 39/00 (2006.01); C07H 21/04 (2006.01); C07K 14/74 (2006.01); C07K 16/18 (2006.01); C07K 16/26 (2006.01); C07K 16/28 (2006.01); C07K 16/30 (2006.01); C07K 16/32 (2006.01); C07K 16/40 (2006.01); C12P 21/06 (2006.01)

CPC (source: EP)

C07K 16/18 (2013.01); C07K 16/26 (2013.01); C07K 16/2803 (2013.01); C07K 16/2833 (2013.01); C07K 16/2896 (2013.01); C07K 16/30 (2013.01); C07K 16/3015 (2013.01); C07K 16/3053 (2013.01); C07K 16/3069 (2013.01); C07K 16/32 (2013.01); C07K 16/40 (2013.01); A61K 2039/505 (2013.01); C07K 2317/32 (2013.01); C07K 2317/34 (2013.01); C07K 2317/732 (2013.01); C07K 2317/734 (2013.01); C07K 2317/92 (2013.01)

Citation (search report)

  • [X] WO 03070752 A2 20030828 - DYAX CORP [US], et al
  • [Y] WO 2005116072 A2 20051208 - WEIDANZ JON A [US], et al
  • [YD] US 2005003483 A1 20050106 - HILDEBRAND WILLIAM H [US], et al
  • [YD] US 2002197672 A1 20021226 - HILDEBRAND WILLIAM H [US], et al
  • [Y] WO 2004011483 A2 20040205 - LUDWIG INST CANCER RES [US], et al
  • [XP] WO 2007030451 A2 20070315 - RECEPTOR LOGIC LTD [US], et al
  • [YD] DANGLES V ET AL: "Tumor-associated antigen human chorionic gonadotropin beta contains numerous antigenic determinants recognized by in vitro-induced CD8+ and CD4+ T lymphocytes", CANCER IMMUNOLOGY AND IMMUNOTHERAPY, SPRINGER-VERLAG, BERLIN, DE LNKD- DOI:10.1007/S00262-001-0248-0, vol. 50, no. 12, 1 February 2002 (2002-02-01), pages 673 - 681, XP002236556, ISSN: 0340-7004
  • [YD] JOOEUN BAE ET AL: "Identification of CD19 and CD20 Peptides for Induction of Antigen-Specific CTLs against B-Cell Malignancies", CLINICAL CANCER RESEARCH, THE AMERICAN ASSOCIATION FOR CANCER RESEARCH, US, vol. 11, 15 February 2005 (2005-02-15), pages 1629 - 1638, XP007912765, ISSN: 1078-0432
  • [YD] JAGER E ET AL: "Simultaneous humoral and cellular immune response against cancer-testis antigen NY-ESO-1: Definition of human histocompatibility leukocyte antigen (HLA)-A2-binding peptide epitopes", THE JOURNAL OF EXPERIMENTAL MEDICINE, ROCKEFELLER UNIVERSITY PRESS, UNITED STATES LNKD- DOI:10.1084/JEM.187.2.265, vol. 187, no. 2, 19 January 1998 (1998-01-19), pages 265 - 270, XP002477113, ISSN: 0022-1007
  • [XP] WITTMAN VAUGHAN P ET AL: "Antibody targeting to a class I MHC-peptide epitope promotes tumor cell death", JOURNAL OF IMMUNOLOGY, AMERICAN ASSOCIATION OF IMMUNOLOGISTS, US, vol. 177, no. 6, 1 September 2006 (2006-09-01), pages 4187 - 4195, XP002514758, ISSN: 0022-1767
  • See references of WO 2007143104A2

Designated contracting state (EPC)

AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR

DOCDB simple family (publication)

WO 2007143104 A2 20071213; WO 2007143104 A8 20080731; AU 2007254859 A1 20071213; CA 2656583 A1 20071213; EP 2026837 A2 20090225; EP 2026837 A4 20100602; IL 195470 A0 20110801

DOCDB simple family (application)

US 2007012958 W 20070601; AU 2007254859 A 20070601; CA 2656583 A 20070601; EP 07777355 A 20070601; IL 19547008 A 20081124